Depressive symptoms and executive function in relation to survival in patients with glioblastoma

Published on Jan 24, 2019in Journal of Neuro-oncology4.13
· DOI :10.1007/S11060-018-03081-Z
Kyle R. Noll11
Estimated H-index: 11
(University of Texas MD Anderson Cancer Center),
Catherine M. Sullaway3
Estimated H-index: 3
(University of Texas MD Anderson Cancer Center),
Jeffrey S. Wefel31
Estimated H-index: 31
(University of Texas MD Anderson Cancer Center)
Sources
Abstract
Introduction Depression and neurocognitive function, particularly executive functioning (EF), have been associated with overall survival (OS) in patients with glioblastoma (GBM). However, the combined effect of depressive symptoms and impaired EF upon OS has not been reported.
đź“– Papers frequently viewed together
References47
Newest
#1Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
#2Mariana E. Bradshaw (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Jeffrey S. Wefel (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 4 authors...
Background: Cancer and treatment-related neurocognitive dysfunction has the potential to significantly disrupt the lives of survivors. While neurocognitive functioning is known to predict aspects of patient-reported quality of life in individuals with glioma, little is known regarding the association between neurocognitive functioning and clinician-rated functional independence. Methods: Newly diagnosed patients with glioma in the left (n = 73; 49% glioblastoma) or right (n = 30; 57% glioblastom...
Source
#1Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
#2Mariana E. Bradshaw (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Jeffrey S. Wefel (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 4 authors...
Objective While neurocognitive functioning (NCF) and mood disturbance share a relationship with health-related quality of life (HRQOL), few studies have examined relationships between these constructs in glioma patients prior to treatment. Methods Newly diagnosed patients with glioma in the left (N = 73; 49% glioblastoma) or right (N = 30; 57% glioblastoma) temporal lobe completed neuropsychological testing and self-report measures of HRQOL (Functional Assessment of Cancer Therapy (FACT)-General...
Source
#1Shelli R. Kesler (University of Texas MD Anderson Cancer Center)H-Index: 18
#2Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
Last. Jeffrey S. WefelH-Index: 31
view all 5 authors...
Mutation of the IDH1 gene is associated with differences in malignant astrocytoma growth characteristics that impact phenotypic severity, including cognitive impairment. We previously demonstrated greater cognitive impairment in patients with IDH1 wild type tumor compared to those with IDH1 mutant, and therefore we hypothesized that brain network organization would be lower in patients with wild type tumors. Volumetric, T1-weighted MRI scans were obtained retrospectively from 35 patients with ID...
Source
#1Beatrice BortolatoH-Index: 13
#2Thomas Hyphantis (RMIT: RMIT University)H-Index: 37
Last. André F. CarvalhoH-Index: 78
view all 12 authors...
Abstract Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation ...
Source
#1Jeffrey S. WefelH-Index: 31
#2Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
Last. Daniel P. Cahill (Harvard University)H-Index: 53
view all 4 authors...
BACKGROUND:Patients with malignant gliomas present with variation in neurocognitive function (NCF) not attributable to lesion size or location alone. A potential contributor is the rate at which tumors grow, or "lesion momentum." Isocitrate dehydrogenase 1 wild type (IDH1-WT) are more proliferative and aggressive than IDH1-mutant (IDH1-M) tumors. We hypothesized that patients with IDH1-WT would exhibit worse NCF than patients with IDH1-M tumors. METHODS:Comprehensive NCF testing was completed in...
Source
#1Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
#2Mateo ZiuH-Index: 18
Last. Jeffrey S. Wefel (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 4 authors...
Patients with glioma frequently suffer from deficits of neurocognitive functioning (NCF), though few studies have assessed NCF in localized glioma patients prior to surgery. One hundred and three patients (M age = 52.0; M education = 14.6 years) with histologically confirmed glioma in the right (RTL: n = 30; 57 % glioblastoma) or left temporal lobe (LTL: n = 73; 49 % glioblastoma) completed presurgical neuropsychological assessment. Impairment of NCF was identified in 75 % of all patients. Notab...
Source
#1Rosaria Sacco (Seconda UniversitĂ  degli Studi di Napoli)H-Index: 15
#2Gabriella Santangelo (Seconda UniversitĂ  degli Studi di Napoli)H-Index: 48
Last. Antonio Gallo (Seconda UniversitĂ  degli Studi di Napoli)H-Index: 29
view all 10 authors...
Depression is the most common psychiatric disorder in multiple sclerosis (MS). Self-report depression scales are frequently used as screening, diagnostic and grading instruments. This study investigated the psychometric properties of the Beck Depression Inventory second edition (BDI-II) for assessing depressive disorders in a sample of Italian MS patients.The sample included 141 consecutive non-demented MS patients who completed the BDI-II and the Chicago Multiscale Depression Inventory (CMDI). ...
Source
#1Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
#2Jeffrey S. Weinberg (University of Texas MD Anderson Cancer Center)H-Index: 43
Last. Jeffrey S. Wefel (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 6 authors...
Abstract Little is known regarding the neurocognitive impact of temporal lobe tumor resection. To clarify subacute surgery-related changes in neurocognitive functioning (NCF) in patients with left (LTL) and right (RTL) temporal lobe glioma. Patients with glioma in the LTL (n = 45) or RTL (n = 19) completed comprehensive pre- and postsurgical neuropsychological assessments. NCF was analyzed with 2-way mixed design repeated-measures analysis of variance, with hemisphere (LTL or RTL) as an independ...
Source
#1Deborah J. Culley (Brigham and Women's Hospital)H-Index: 36
#2Gregory CrosbyH-Index: 40
Surgery sets the old brain on fire and prehabilitation is a fire retardant. That’s conclusion of an interesting study by Kawano et. al.1 in this issue of the Journal. Specifically, they hypothesized that the old brain is more vulnerable than a young one to surgery-induced neuroinflammation because its innate immune cells, principally microglia, develop an exaggerated inflammatory response to a peripheral surgical procedure. Furthermore, in a novel twist, Kawano et. al. theorized that preoperativ...
Source
#1Kyle R. NollH-Index: 11
#2Catherine M. Sullaway (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Jeffrey S. WefelH-Index: 31
view all 5 authors...
Glioma comprises the vast majority of all malignant primary brain tumors.1 These tumors often disrupt cerebral function through direct mechanisms such as destruction of brain tissue, as well as more indirect means, including compression, displacement, and ischemia.2 As a result, most patients exhibit some impairment of neurocognitive function (NCF), even early in the disease course.3,4 However, when compared with patients with acute lesions related to stroke or trauma, individuals with brain tum...
Source
Cited By16
Newest
#1Kathryn M. Field (Royal Melbourne Hospital)H-Index: 19
#2Elizabeth H Barnes (National Health and Medical Research Council)H-Index: 26
Last. Lawrence CherH-Index: 17
view all 9 authors...
Abstract null null Assessment of neurocognitive function (NCF) is important in brain tumor clinical trials, however there are varying methodologies available. We used the Cogstate computerized NCF testing battery and the mini-mental state examination (MMSE) to prospectively assess cognition in adult patients with recurrent glioblastoma (GBM) enrolled in the CABARET randomized phase II clinical trial of bevacizumab versus bevacizumab plus carboplatin chemotherapy. We determined completion rates; ...
Source
#1Kyle R. Noll (University of Texas MD Anderson Cancer Center)H-Index: 11
#2Amanda L King (NIH: National Institutes of Health)H-Index: 1
Last. Jeffrey S. Wefel (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 6 authors...
Patients with brain tumors experience great symptom burden across various domains of functioning, with associated decreases in health-related quality of life and general well-being. Impaired neurocognitive functioning is among the primary concerns of these patients. Unfortunately, most patients will experience such impairment at some point in the disease. However, impaired neurocognitive functioning, symptom burden, and well-being vary according numerous patient-, tumor-, and treatment-related f...
Source
#1H. Bruhn (Linköping University)H-Index: 1
#2Ida Blystad (Linköping University)H-Index: 7
Last. Jonas Lind (Linköping University)H-Index: 2
view all 8 authors...
OBJECTIVES Seizures as presenting symptom of glioblastoma (GBM) are known to predict prolonged survival, whereas the clinical impact of other initial symptoms is less known. Our main objective was to evaluate the influence of different presenting symptoms on survival in a clinical setting. We also assessed lead times, tumour size and localization. METHODS Medical records of 189 GBM patients were reviewed regarding the first medical appointment, presenting symptom/s, date of diagnostic radiology ...
Source
#1Ann Helen Torstveit (University of Oslo)H-Index: 1
#2Christine Miaskowski (UCSF: University of California, San Francisco)H-Index: 102
Last. Inger Utne (University of Oslo)H-Index: 9
view all 9 authors...
Abstract null null Purpose null To evaluate for inter-individual differences in two subjective measures of functional status in older patients (n = 112), as well as to determine which demographic, clinical, and symptom characteristics, and levels of cognitive function, were associated with initial levels and with the trajectory of the two measures. null null null Methods null Functional status was assessed using self-report measures of physical function (PF) and role function (RF) from the Europ...
Source
#2Hannah Brock (Leipzig University)
Last. JĂĽrgen MeixensbergerH-Index: 30
view all 0 authors...
Objective. We aimed to assess psychological distress in patients with intracranial neoplasia, a group of patients who suffer from severe functional, neurocognitive and neuropsychological side effects, resulting in high emotional distress. Methods. We conducted a cross-sectional study, including inpatients with brain tumours. Eligible patients completed validated self-report questionnaires measuring depression, anxiety, distress, symptoms of posttraumatic stress disorder (PTSD), fear of progressi...
Source
#1Ryan Merrell (NorthShore University HealthSystem)H-Index: 20
#2Kelly Claire Simon (NorthShore University HealthSystem)H-Index: 3
Last. Demetrius M. Maraganore (Tulane University)H-Index: 19
view all 9 authors...
Abstract null null Objective null To develop and implement a customized toolkit within the electronic medical record (EMR) to standardize care of patients with brain tumors. null null null Patients and Methods null We built a customized structured clinical documentation support toolkit to capture standardized data at office visits. We detail the process by which this toolkit was conceptualized and developed. Toolkit development was a physician-led process to determine a work flow and necessary e...
Source
#1Michael W. Parsons (Harvard University)H-Index: 17
#2Jorg Dietrich (Harvard University)H-Index: 33
Cognitive symptoms occur in almost all patients with brain tumors at varying points in the disease course. Deficits in neurocognitive function may be caused by the tumor itself, treatment (surgery, radiation, or chemotherapy), or other complicating factors (e.g., seizures, fatigue, mood disturbance) and can have a profound effect on functional independence and quality of life. Assessment of neurocognitive function is an important part of comprehensive care of patients with brain tumors. In the n...
Source
Significant advances in our understanding of the molecular genetics of pediatric and adult brain tumors and the resulting rapid expansion of clinical molecular neuropathology have led to improvements in diagnostic accuracy and identified new targets for therapy. Moreover, there have been major improvements in all facets of clinical care, including imaging, surgery, radiation and supportive care. In selected cohorts of patients, targeted and immunotherapies have resulted in improved patient outco...
Source
#1FlĂłra John (WSU: Wayne State University)H-Index: 3
#2Sharon K. Michelhaugh (WSU: Wayne State University)H-Index: 20
Last. Csaba JuhászH-Index: 56
view all 5 authors...
Patients with brain tumors have an increased risk for depression, whose underlying pathomechanism may involve dysregulated tryptophan/kynurenine metabolism. In this study, we analyzed the relation of depressive symptoms to clinical and tumor characteristics as well as cerebral and systemic tryptophan metabolism in patients with primary brain tumors. Sixty patients with newly-diagnosed or recurrent primary brain tumor underwent testing with the Beck Depression Inventory-II (BDI-II), and 34 patien...
Source
#1L. DinapoliH-Index: 1
#3Nicola DinapoliH-Index: 24
Last. Mario Balducci (UCSC: Catholic University of the Sacred Heart)H-Index: 25
view all 14 authors...
PURPOSE Psychological distress in primary malignant brain tumour (PMBT) patients is associated with poorer outcomes. Radiotherapy (RT) often induces side effects that significantly influence patients' quality of life (QoL), with potential impact on survival. We evaluated distress, anxiety, depression, and QoL over time to identify patients with difficulties in these areas who required more intense psychological support. METHODS Psychological questionnaires-Distress Thermometer (DT), Hospital Anx...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.