Long Non-Coding RNAs Play a Role in the Pathogenesis of Psoriatic Arthritis by Regulating MicroRNAs and Genes Involved in Inflammation and Metabolic Syndrome

Psoriatic arthritis (PsA) is an inflammatory arthritis, characterised by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10% to 30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However an autoinflammatory...