Antonio Puccetti
Istituto Giannina Gaslini
PathologyAntigenMolecular biologyVirologyAntibodyAutoantibodyApoptosisEpitopeImmunologyArthritisMolecular mimicryAutoimmune diseaseDiseaseHuman cytomegalovirusAutoimmunityImmunoglobulin GPathogenesisMedicineBiologyImmune system
103Publications
24H-index
2,636Citations
Publications 97
Newest
#1Elisa Tinazzi (University of Verona)H-Index: 21
#2Nicola Osti (University of Verona)H-Index: 1
Last. Claudio Lunardi (University of Verona)H-Index: 35
view all 11 authors...
Abstract Immune Thrombocitopenic Purpura (ITP) is an autoimmune disease characterized by antibody-mediated platelet destruction and variable reduced platelet production. Besides antibody-mediated platelet destruction, new pathogenic mechanisms have been reported to be involved in reducing platelet count. Among these, desialylation is one of the most recent and innovative mechanisms that has been found to be implied, at least in part, in non-antibody mediated platelet clearance. Common Variable I...
2 CitationsSource
#1M. Dolcino (University of Verona)H-Index: 4
#1Marzia Dolcino (University of Verona)H-Index: 14
Last. Claudio Lunardi (University of Verona)H-Index: 35
view all 4 authors...
Fibromyalgia is a chronic disorder characterized by widespread pain and by several non-pain symptoms. Autoimmunity, small fiber neuropathy and neuroinflammation have been suggested to be involved in the pathogenesis of the disease. We have investigated the gene expression profile in peripheral blood mononuclear cells obtained from ten patients and ten healthy subjects. Of the 545,500 transcripts analyzed, 1673 resulted modulated in fibromyalgic patients. The majority of these genes are involved ...
3 CitationsSource
#1Claudio VitaliH-Index: 39
#2M. Dolcino (University of Verona)H-Index: 4
Last. Antonio Puccetti (UniGe: University of Genoa)H-Index: 24
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Objective To investigate the gene expression profile in patients with Sjogren's syndrome that is characterized by different clinical phenotypes.
Source
#1M. Dolcino (University of Verona)H-Index: 4
#1Marzia Dolcino (University of Verona)H-Index: 14
Last. Claudio Lunardi (University of Verona)H-Index: 35
view all 6 authors...
Primary Sjogren’s syndrome (pSjS) is a chronic systemic autoimmune disorder, primarily affecting exocrine glands; its pathogenesis is still unclear. Long non-coding RNAs (lncRNAs) are thought to play a role in the pathogenesis of autoimmune diseases and a comprehensive analysis of lncRNAs expression in pSjS is still lacking. To this aim, the expression of more than 540,000 human transcripts, including those ascribed to more than 50,000 lncRNAs is profiled at the same time, in a cohort of 16 peri...
6 CitationsSource
#1M. Dolcino (University of Verona)H-Index: 4
#1Marzia Dolcino (University of Verona)H-Index: 14
Last. Claudio Lunardi (University of Verona)H-Index: 35
view all 4 authors...
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease driven by genetic, environmental and epigenetic factors. Long non-coding RNAs (LncRNAs) are a key component of the epigenetic mechanisms and are known to be involved in the development of autoimmune diseases. In this work we aimed to identify significantly differentially expressed LncRNAs (DE-LncRNAs) that are functionally connected to modulated genes strictly associated with RA. In total, 542,500 transcripts have been profil...
5 CitationsSource
#1M. Dolcino (University of Verona)H-Index: 4
#1Marzia Dolcino (University of Verona)H-Index: 14
Last. Claudio Lunardi (University of Verona)H-Index: 35
view all 4 authors...
Systemic sclerosis (SSc) is an autoimmune disease characterized by three main features: vasculopathy, immune system dysregulation and fibrosis. Long non-coding RNAs (lncRNAs) may play a role in the pathogenesis of autoimmune diseases and a comprehensive analysis of lncRNAs expression in SSc is still lacking. We profiled 542,500 transcripts in peripheral blood mononuclear cells (PBMCs) from 20 SSc patients and 20 healthy donors using Clariom D arrays, confirming the results by Reverse Transcripti...
16 CitationsSource
#1M. Dolcino (University of Verona)H-Index: 4
#1Marzia Dolcino (University of Verona)H-Index: 14
Last. Antonio PuccettiH-Index: 24
view all 7 authors...
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterised by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10% to 30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However an autoinflammatory origin has recently been proposed. Long noncoding ...
13 CitationsSource
#1Claudio VitaliH-Index: 39
#2M. Dolcino (University of Verona)H-Index: 4
Last. Antonio PuccettiH-Index: 24
view all 9 authors...
Background Different phenotypes characterise the clinical spectrum of primary Sjogren’s syndrome (SjS). Patients with a clinical expression limited to glandular features (GFs) are classically distinguished from patients with extra-glandular manifestations (EGMs). The former patients often complain higher level of fatigue and widespread pain (WP). (Segal et al. 2013) This suggests that gene expression pattern may be different in the two subgroups. Objectives To investigate the differences of gene...
Source
#1Antonio PuccettiH-Index: 24
#2Andrea PelosiH-Index: 12
Last. Marzia Dolcino (University of Verona)H-Index: 14
view all 6 authors...
Background. Behcet’s disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions. MicroRNAs (miRNAs) are key regulators of immune responses. Differential expression of miRNAs has been reported in several inflammatory autoimmune diseases; however, their role in BD is not fully elucidated. We aimed to identify miRNA expression signatures associated with BD and to investigate their potential implication in the disease pathogenesis. ...
12 CitationsSource
#1Antonio PuccettiH-Index: 4
#1Antonio PuccettiH-Index: 24
Last. Marzia Dolcino (University of Verona)H-Index: 14
view all 9 authors...
Behcet disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions. Disease etiopathogenesis is still unclear. We aim to elucidate some aspects of BD pathogenesis and to identify specific gene signatures in peripheral blood cells (PBCs) of patients with active disease using novel gene expression and network analysis. 179 genes were modulated in 10 PBCs of BD patients when compared to 10 healthy donors. Among differentially expres...
14 CitationsSource