Frontiers in Immunology
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#1Amber G. BozwardH-Index: 2
#2Vincenzo RoncaH-Index: 3
Last. Ye Htun OoH-Index: 31
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#1Rongrong LiuH-Index: 3
Last. Shijuan ShanH-Index: 9
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#1Lei HanH-Index: 5
Last. Haiyan ZhuH-Index: 6
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#1Martina S. Wesley (Duke University)
#2Kelvin T. Chiong (Duke University)
Last. David Beaumont (Duke University)H-Index: 3
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The outcome of the recent Antibody Mediated Prevention (AMP) trials that tested infusion of the broadly neutralizing antibody (bnAb) VRC01 provides proof of concept for blocking infection from sensitive HIV-1 strains. These results also open up the possibility that triple combinations of bnAbs such as PGT121, PGDM1400, as well as long-lasting LS variants such as VRC07-523 LS, have immunoprophylactic potential. PGT121 and PGDM1400 target the HIV-1 V3 and V2 glycan regions of the gp120 envelope pr...
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#1Elise M.N. FerreH-Index: 10
#2Monica M. SchmittH-Index: 1
Last. Jenna BergersonH-Index: 8
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#1Yang Liu (WHU: Wuhan University)
#2Yankang Wu (WHU: Wuhan University)
Last. Yun Zhou (HUST: Huazhong University of Science and Technology)
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The COVID-19 pandemic caused by SARS-CoV-2 infection is a global crisis, however, our current understanding of the host immune response to SARS-CoV-2 infection remains limited. Herein, we performed RNA sequencing using peripheral blood from acute and convalescent patients, and interrogated the dynamic changes of adaptive immune response to SARS-CoV-2 infection over time. Our results revealed numerous alterations in these cohorts in terms of gene expression profiles and the features of immune rep...
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#1Michal RudnikH-Index: 2
#2Amela HukaraH-Index: 1
Last. Oliver DistlerH-Index: 98
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#1James P. Barrett (UMB: University of Maryland, Baltimore)H-Index: 11
#2Susan Knoblach (GW: George Washington University)H-Index: 17
Last. David J. Loane (Trinity College, Dublin)H-Index: 41
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Aging adversely affects inflammatory processes in the brain, which has important implications in the progression of neurodegenerative disease. Following traumatic brain injury (TBI), aged animals exhibit worsened neurological function and exacerbated microglial-associated neuroinflammation. Type I Interferons (IFN-I) contribute to the development of TBI neuropathology. Further, the Cyclic GMP-AMP Synthase (cGAS) and Stimulator of Interferon Genes (STING) pathway, a key inducer of IFN-I responses...
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#1Gang Liu (CSU: Central South University)
#2Wenxuan Zhou (CSU: Central South University)
Last. Liansheng Gong (CSU: Central South University)
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Hepatocellular carcinoma (HCC) is an aggressive liver tumor that occurs from chronic liver disease, with high mortality rate limited treatment. Immune checkpoint inhibitors were successfully introduced to cancer therapy, among which inhibitors of programmed death ligand-1 (PD-L1) and receptor (PD-1) are more commonly selected for the treatment of HCC patients through along with through the combination of immunotherapy, including combined anti-vascular and dual immunotherapy. In this case study, ...
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Virology
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