Frontiers in Immunology
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#1Frederik Staels (KUL: KU Leuven)H-Index: 5
#2Tom Collignon (KUL: KU Leuven)
Last. Rik Schrijvers (KUL: KU Leuven)H-Index: 18
view all 9 authors...
Primary immunodeficiencies (PID) are a heterogenous group of disorders driven by genetic defects that functionally impact the development and/or function of the innate and/or adaptive immune system. The majority of these disorders are thought to have polygenic background. However, the use of next-generation sequencing in PID patients has led to an increasing identification of monogenic causes, unravelling the exact pathophysiology of the disease and allowing the development of more targeted trea...
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#1Martin Killian (CNRS: French National Centre for Scientific Research)
#2Fabien ColaoneH-Index: 2
Last. Mireille Thomas (INSERM: Inserm)H-Index: 10
view all 15 authors...
Sjogren’s syndrome (SjS) is a frequent systemic autoimmune disease responsible for a major decrease in patients’ quality of life, potentially leading to life-threatening conditions while facing an unmet therapeutic need. Hence, we assessed the immunogenicity, efficacy, and tolerance of IFN-Kinoid (IFN-K), an anti-IFNα vaccination strategy, in a well-known mouse model of systemic autoimmunity with SjS-like features: MRL/MpJ-Faslpr/lpr (MRL/lpr) mice. Two cohorts (with ISA51 or SWE01 as adjuvants)...
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#1Surekha NimmaH-Index: 1
#2W. GuH-Index: 3
Last. Sulin Li
view all 14 authors...
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#1Alissa Cait (Malaghan Institute of Medical Research)H-Index: 9
#2Anna Mooney (Malaghan Institute of Medical Research)H-Index: 2
Last. Jeffry Tang (Malaghan Institute of Medical Research)H-Index: 1
view all 25 authors...
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fi...
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#1Chiara AgostinisH-Index: 21
#2Alessandro MangognaH-Index: 10
Last. Roberta Bulla (UNITS: University of Trieste)H-Index: 27
view all 7 authors...
COVID-19 is characterized by viral-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system via its cross-talk with contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infe...
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#1Ning HuangH-Index: 25
Last. Jie QiaoH-Index: 62
view all 5 authors...
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#1Anna Hogendorf (Medical University of Łódź)H-Index: 5
#2Maciej Zieliński (MUG: Gdańsk Medical University)H-Index: 9
Last. Małgorzata Piotrowicz (Memorial Hospital of South Bend)H-Index: 6
view all 22 authors...
Introduction: Autoimmune disorders, IgA deficiency and allergies seem to be common among individuals with 18 q deletion syndrome [OMIM 601808]. We aimed to determine the prevalence, mechanism and genetic background of autoimmunity, immune deficiency and allergy in a cohort of patients with 18q deletions. Material and methods: Medical registries and social media were used to recruit the patients. Microarray oligonucleotide comparative genomic hybridization (aCGH) (Agilent, USA) was performed in a...
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#1Zandhuis Nd (UvA: University of Amsterdam)H-Index: 2
#2Benoit P Nicolet (UvA: University of Amsterdam)H-Index: 7
Last. Monika C. Wolkers (UvA: University of Amsterdam)H-Index: 17
view all 3 authors...
B cells and T cells are key players in the defence against infections and malignancies. To exert their function, B cells and T cells differentiate into effector and memory cells. Tight regulation of these differentiation processes is key to prevent their malfunction, which can result in life-threatening disease. Lymphocyte differentiation relies on the appropriate timing and dosage of regulatory molecules, and post-transcriptional gene regulation (PTR) is a key player herein. PTR includes the re...
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