The Endoplasmic Reticulum Stress and Unfolded Protein Responses in Sulfur Mustard induced Mouse Skin Wound Repair

The endoplasmic reticulum stress (ERS) pathways activate the unfolded protein response (UPR) to mediate cell survival against severe stress in an attempt to prevent ERS mediated apoptosis. Sulfur mustard (SM), a chemical warfare vesicating agent, causes significant delayed wound repair in skin. This study explored the contribution of UPR and ERS to SM cutaneous injury in mice. We performed time course studies using the mouse ear vesicant model...