Yoke-Chen Chang
Rutgers University
Matrix metalloproteinaseDownregulation and upregulationPathologyMolecular biologyEndoplasmic reticulumChemistryBasement membraneCorneaDermisNitrogen mustardHairlessLamininWound healingSulfur mustardMouse skinEpitheliumBiochemistryMedicineBiologyCell biologyPharmacology
32Publications
7H-index
191Citations
Publications 32
Newest
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#1Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Marion K. Gordon (RU: Rutgers University)H-Index: 21
view all 8 authors...
Amino-Plex (SM1997) is a spray or liquid cosmeceutical that has been used for skin dryness, aging, or sun exposure. Its formulation includes electrolytes, trace minerals, amino acids, peptides, nucleosides and nucleotides, all substances that are less than 10 kDa. It is designed to increase oxygen levels in cells, improve glucose transport, stimulate ATP synthesis, and stimulate collagen formation, actions that can help facilitate repair of damaged cells. It also supports collagen synthesis and ...
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#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...
Abstract Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major component of the BMZ at the dermal-epidermal junction. In the present studies, a type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), was tested for it...
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#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Last. Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
view all 6 authors...
1 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2Selina MuhnH-Index: 1
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita Hahn (RU: Rutgers University)H-Index: 3
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...
#1Yoke-Chen ChangH-Index: 7
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
Source
#1Yoke-Chen ChangH-Index: 7
#2Rita A. HahnH-Index: 8
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
Source
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Marion K. Gordon (RU: Rutgers University)H-Index: 21
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 3 authors...
Sulfur Mustard (SM) is a potent vesicant or blistering agent. It is a highly reactive bi-functional alkylating agent that cross links proteins, DNA, and other cellular components. Laminin 332 is a heterotrimer glycoprotein and a crucial skin component that attaches the epidermal basal keratinocytes to the dermis. SM wounds histologically appear similar to Epidermolysis Bullosa (EB), human genetic blistering diseases that involve genetic changes in laminin 332. The specific mechanism of action of...
3 Citations
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 6 authors...