James D. Wang
Rutgers University
Messenger RNAAnatomyInternal medicineDownregulation and upregulationCell migrationUnfolded protein responseSurgeryPathologyOncologyMolecular biologyGap junctionEndoplasmic reticulumChemistryApoptosisHeat shock proteinBasement membraneWestern blotCancer screeningBone mineralInflammationHyperplasiaImmunofluorescenceNitrogen mustardHairlessMalignancyLamininWound healingSulfur mustardEdemaKeratinocyte migrationSkin InjuryDynamic modulationSecond primary cancerCancer specific survivalTreated mouseSkin woundMouse skinPostmenopausal womenAntisense oligodeoxynucleotidesInjury modelPhysiologySenescenceColorectal cancerBiochemistryMedicineKeratinIn situ hybridizationBiologyCell biologyCancer cellPharmacology
10Publications
2H-index
36Citations
Publications 10
Newest
#1Yoke Chen Chang (RU: Rutgers University)H-Index: 3
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 8 authors...
: Laminin-332 is a basement membrane protein composed of three genetically distinct polypeptide chains that actively promote both skin epidermal cell adhesion and migration. Proteolytic fragments of the laminin γ2 chain stimulate migration and scattering of keratinocytes and cancer cells. Sulfur mustard (SM) is a bifunctional alkylating agent that induces separation of basal keratinocytes from the dermal-epidermal junction and invokes a strong inflammatory response leading to delayed wound repai...
1 CitationsSource
#1Larysa Sanchez (RU: Rutgers University)H-Index: 6
#2Narjust Duma (RU: Rutgers University)H-Index: 9
Last. Martin Gutierrez (Hackensack University Medical Center)H-Index: 39
view all 10 authors...
e14691 Background: Advances in cancer screening and treatment in the past 20 years have improved cancer specific survival rates, raising questions regarding second primary malignancies and the pathologic characteristics of those tumors. The aim of this study was to investigate the characteristics of colorectal (CRC) as a second primary malignancy. Methods: We reviewed the records of 1602 patients (pts) diagnosed with CRC between 2005 and 2013 in our institution. Demographics, tumor characteristi...
Source
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 13 authors...
Sulfur mustard (bis(2-chloroethyl) sulfide, SM) is a highly reactive bifunctional alkylating agent inducing edema, inflammation, and the formation of fluid-filled blisters in the skin. Medical countermeasures against SM-induced cutaneous injury have yet to be established. In the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (NDH 4338) designed to target cyclooxygenase 2 (COX2), an enzyme that generates inflammatory eicosanoids, and acetylcholinesterase, an enzyme med...
18 CitationsSource
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 6 authors...
Gap junction communication is tightly regulated in skin wound healing. Studies showed that targeting of connexin43 (Cx43) improves skin wound repair in diabetes. Vesicant induced skin injury result...
#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 7 authors...
The endoplasmic reticulum (ER) stress response is a cell survival pathway upregulated when cells are under severe stress. Severely damaged mouse ear skin exposed to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), resulted in increased expression of ER chaperone proteins that accompany misfolded and incorrectly made proteins targeted for degradation. Time course studies with SM using the mouse ear vesicant model (MEVM) showed progressive histopathologic changes including edema, sepa...
17 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2James D. WangH-Index: 2
Last. Donald R. GereckeH-Index: 18
view all 4 authors...
#1Yoke-Chen ChangH-Index: 7
#2James D. WangH-Index: 2
Last. Donald R. GereckeH-Index: 18
view all 0 authors...
Source
#1Yoke-Chen ChangH-Index: 7
#2James D. WangH-Index: 2
Last. Donald R. GereckeH-Index: 18
view all 4 authors...
#1Yoke-Chen ChangH-Index: 7
#2James D. WangH-Index: 2
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
#1T. A. Hardwick (RU: Rutgers University)H-Index: 1
#2S. B. Hevmsfield (Columbia University)
Last. Sue A. ShapsesH-Index: 46
view all 7 authors...