Donald R. Gerecke
Rutgers University
GeneMatrix metalloproteinaseDownregulation and upregulationPathologyMolecular biologyChemistryImmunologyBasement membraneInflammationNitrogen mustardLamininWound healingSulfur mustardMouse skinCancer researchBiochemistryMedicineBiologyCell biologyPharmacology
86Publications
18H-index
1,215Citations
Publications 86
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#1Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Marion K. Gordon (RU: Rutgers University)H-Index: 21
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Amino-Plex (SM1997) is a spray or liquid cosmeceutical that has been used for skin dryness, aging, or sun exposure. Its formulation includes electrolytes, trace minerals, amino acids, peptides, nucleosides and nucleotides, all substances that are less than 10 kDa. It is designed to increase oxygen levels in cells, improve glucose transport, stimulate ATP synthesis, and stimulate collagen formation, actions that can help facilitate repair of damaged cells. It also supports collagen synthesis and ...
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#1Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...
Abstract Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major component of the BMZ at the dermal-epidermal junction. In the present studies, a type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), was tested for it...
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#1Yoke Chen Chang (RU: Rutgers University)H-Index: 3
#2James D. Wang (RU: Rutgers University)H-Index: 2
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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: Laminin-332 is a basement membrane protein composed of three genetically distinct polypeptide chains that actively promote both skin epidermal cell adhesion and migration. Proteolytic fragments of the laminin γ2 chain stimulate migration and scattering of keratinocytes and cancer cells. Sulfur mustard (SM) is a bifunctional alkylating agent that induces separation of basal keratinocytes from the dermal-epidermal junction and invokes a strong inflammatory response leading to delayed wound repai...
1 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2Selina MuhnH-Index: 1
Last. Donald R. GereckeH-Index: 18
view all 5 authors...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Last. Yoke-Chen Chang (RU: Rutgers University)H-Index: 7
view all 6 authors...
1 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita Hahn (RU: Rutgers University)H-Index: 3
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
view all 5 authors...
#1Yoke-Chen ChangH-Index: 7
Last. Donald R. GereckeH-Index: 18
view all 0 authors...
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#1Yoke Chen Chang (RU: Rutgers University)H-Index: 3
#2Melannie Soriano (RU: Rutgers University)H-Index: 1
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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Abstract Sulfur mustard (2,2′-dichlorodiethyl sulfide, SM) is a chemical warfare agent that generates an inflammatory response in the skin and causes severe tissue damage and blistering. In earlier studies, we identified cutaneous damage induced by SM in mouse ear skin including edema, erythema, epidermal hyperplasia and microblistering. The present work was focused on determining if SM-induced injury was associated with alterations in mRNA and protein expression of specific cytokines and chemok...
5 CitationsSource
#1Yoke-Chen ChangH-Index: 7
#2Rita A. HahnH-Index: 8
Last. Donald R. GereckeH-Index: 18
view all 0 authors...
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