The FASEB Journal
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#1Eiji Munetsuna (Fujita Health University)H-Index: 15
#2Hiroya Yamada (Fujita Health University)H-Index: 17
Last. Hiroaki Ishikawa (Fujita Health University)H-Index: 12
view all 16 authors...
Given that fructose consumption has increased by more than 10-fold in recent decades, it is possible that excess maternal fructose consumption causes harmful effects in the next generation. This study attempted to elucidate the mechanism of the harmful effects of excessive maternal fructose intake from the perspective of offspring liver function. Female rats during gestation and lactation were fed water containing fructose, and their offspring were fed normal water. We attempted to elucidate the...
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#1Heng Zhang (CAU: China Agricultural University)H-Index: 4
#2Yangfei Xue (CAU: China Agricultural University)H-Index: 1
Last. Qun Liu (CAU: China Agricultural University)H-Index: 15
view all 5 authors...
Toxoplasma gondii is an obligate intracellular apicomplexan parasite causing lethal diseases in immunocompromised patients. UBL-UBA shuttle proteins (DDI1, RAD23, and DSK2) are important components of the ubiquitin-proteasome system. By degrading ubiquitinated proteins, UBL-UBA shuttle proteins regulate many cellular processes. However, the specific processes regulated by UBL-UBA shuttle proteins remain elusive. Here, we revealed that the deletion of shuttle proteins results in a selective accum...
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#1Nelson E. Bruno (TSRI: Scripps Research Institute)H-Index: 6
#2Jerome C. Nwachukwu (TSRI: Scripps Research Institute)H-Index: 20
Last. Sue C. Bodine (UI: University of Iowa)H-Index: 39
view all 12 authors...
The Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators drive Creb1-mediated transcription effects on metabolism in many tissues, but the in vivo effects of Crtc2/Creb1 transcription on skeletal muscle metabolism are not known. Skeletal muscle-specific overexpression of Crtc2 (Crtc2 mice) induced greater mitochondrial activity, metabolic flux capacity for both carbohydrates and fats, improved glucose tolerance and insulin sensitivity, and increased oxidative ...
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#1Jizhe Hao (AMU: Aix-Marseille University)H-Index: 12
#2Lucie Brosse (AMU: Aix-Marseille University)H-Index: 3
Last. Patrick Delmas (AMU: Aix-Marseille University)H-Index: 29
view all 9 authors...
Mepyramine, a first-generation antihistamine targeting the histamine H(1) receptor, was extensively prescribed to patients suffering from allergic reactions and urticaria. Serious adverse effects, especially in case of overdose, were frequently reported, including drowsiness, impaired thinking, convulsion, and coma. Many of these side effects were associated with the blockade of histaminergic or cholinergic receptors. Here we show that mepyramine directly inhibits a variety of voltage-gated sodi...
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#1Meriem Hamdi (UZH: University of Zurich)H-Index: 10
#2K. Cañón-Beltrán (CSIC: Spanish National Research Council)H-Index: 3
Last. D. Rizos (CSIC: Spanish National Research Council)H-Index: 3
view all 9 authors...
Extracellular vesicles (EVs) found in various biological fluids and particularly in reproductive fluids, have gained considerable attention for their possible role in cell- to- cell communication. Among, the different bioactive molecules cargos of EVs, MicroRNAs (miRNAs) are emerging as promising diagnostic biomarkers with high clinical potential. Aiming to understand the roles of EVs in bovine reproductive tract, we intended to characterize and profile the EVs of oviduct and uterine fluids (OF-...
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#1Roshan Kumari (UTHSC: University of Tennessee Health Science Center)
#2Maria Johnson Irudayam (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Chester W. Brown (Boston Children's Hospital)H-Index: 31
view all 8 authors...
Adipose tissue is the primary site of energy storage, playing important roles in health. While adipose research largely focuses on obesity, fat also has other critical functions, producing adipocytokines and contributing to normal nutrient metabolism, which in turn play important roles in satiety and total energy homeostasis. SMAD2/3 proteins are downstream mediators of activin signaling, which regulate critical preadipocyte and mature adipocyte functions. Smad2 global knockout mice exhibit embr...
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#1Rui F. SimõesH-Index: 4
#2Rute Pino (University of Coimbra)
Last. Francisco B. Pereira (University of Coimbra)H-Index: 19
view all 9 authors...
Alterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study mitochondrial trafficking events rely on parameters that are primarily altered in later stages of neurodegeneration. Our objective was to establish a reliable applied statistical analysis to detect early alterations in neuronal mitochondrial trafficking. We propose a novel quantitative analysis of mitochondria tra...
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#1Thoru Pederson (University of Massachusetts Amherst)H-Index: 66
#1Thoru Pederson (University of Massachusetts Amherst)
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#1Ruxandra F. Sîrbulescu (Harvard University)H-Index: 17
#2Akshay Mamidi (Harvard University)
Last. Michael J. Whalen (Harvard University)H-Index: 49
view all 12 authors...
Exogenously applied mature naive B220+ /CD19+ /IgM+ /IgD+ B cells are strongly protective in the context of tissue injury. However, the mechanisms by which B cells detect tissue injury and aid repair remain elusive. Here, we show in distinct models of skin and brain injury that MyD88-dependent toll-like receptor (TLR) signaling through TLR2/6 and TLR4 is essential for the protective benefit of B cells in vivo, while B cell-specific deletion of MyD88 abrogated this effect. The B cell response to ...
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#1Amalia Ruiz-Serrano (UZH: University of Zurich)H-Index: 2
#2Josep M Monné Rodríguez (UZH: University of Zurich)H-Index: 6
Last. Carsten A. Wagner (UZH: University of Zurich)H-Index: 79
view all 13 authors...
OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, the physiological function of OTUB1 is unknown. Here, we show that constitutive whole-body Otub1 deletion in mice leads to perinatal lethality by asphyxiation. Analysis of (single-cell) RNA sequencing and proteome data demonstrated that OTUB1 is ...
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