The FASEB Journal
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#1Jenica H. Kakadia (UWO: University of Western Ontario)
#2Kyle K. Biggar (Carleton University)H-Index: 25
Last. Madhulika B. Gupta (UWO: University of Western Ontario)H-Index: 14
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Hypoxia increases fetal hepatic insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation mediated by mechanistic target of rapamycin (mTOR) inhibition. Whether maternal nutrient restriction (MNR) causes fetal hypoxia remains unclear. We used fetal liver from a baboon (Papio sp.) model of intrauterine growth restriction due to MNR (70% global diet of Control) and liver hepatocellular carcinoma (HepG2) cells as a model for human fetal hepatocytes and tested the hypothesis that mTOR-m...
#1Hongyin Yu (HMU: Harbin Medical University)H-Index: 1
#2Zelong Wang (HMU: Harbin Medical University)
Last. Jialan Shi (HMU: Harbin Medical University)H-Index: 1
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The link between serum uric acid (SUA) and the risk of venous thromboembolism (VTE) is well established. Recent data suggested a causative role of UA in endothelial cells (ECs) dysfunction. However, the molecular mechanism of high UA on thrombogenesis is unknown. We investigate whether high UA induce phosphatidylserine (PS) externalization and microparticle (MP) shedding in cultured EC, and contribute to UA-induced hypercoagulable state. In the present study, we demonstrate that UA induces PS ex...
#1Mengling Ye (WHU: Wuhan University)H-Index: 2
#2Cheng Wang (WHU: Wuhan University)H-Index: 1
Last. Xiaoqing Li (HUST: Huazhong University of Science and Technology)H-Index: 12
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Long noncoding RNAs (lncRNAs) are central regulators of the inflammatory response and play an important role in inflammatory diseases. PINT has been reported to be involved in embryonic development and tumorigenesis. However, the potential functions of PINT in the innate immune system are largely unknown. Here, we revealed the transcriptional regulation of inflammatory genes by PINT, whose expression is primarily dependent on the NF-κB signaling pathway in human and mouse macrophage and intestin...
#1María Abellán-Álvaro (University of Valencia)H-Index: 2
#2Guillermo Ayala (University of Valencia)H-Index: 19
Last. Enrique Lanuza (University of Valencia)H-Index: 32
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During lactation, adult female mice display aggressive responses toward male intruders, triggered by male-derived chemosensory signals. This aggressive behavior is not shown by pup-sensitized virgin females sharing pup care with dams. The genetic mechanisms underlying the switch from attraction to aggression are unknown. In this work, we investigate the differential gene expression in lactating females expressing maternal aggression compared to pup-sensitized virgin females in the medial amygdal...
#1Li Guangdong (CAU: China Agricultural University)H-Index: 5
#2Dongying Lv (CAU: China Agricultural University)H-Index: 5
Last. Wenkui Ma (CAU: China Agricultural University)
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Melatonin is a pleiotropic molecule with a variety of biological functions, which include its immunoregulatory action in mammals. Brucellosis is a worldwide endemic zoonotic disease caused by the Brucella, which not only causes huge economic losses for the livestock industry but also impacts human health. To target this problem, in current study, two marker-free transgenic sheep overexpressing melatonin synthetic enzyme ASMT (acetylserotonin O-methyltransferase) gene were generated and these mel...
#1Lu Yang (SUS: Shanghai University of Sport)
#2Dong-Xia Li (SUS: Shanghai University of Sport)H-Index: 4
Last. Yu-Jian Liu (SUS: Shanghai University of Sport)H-Index: 9
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Exercise training exerts protective effects against diabetic nephropathy. This study aimed to investigate whether exercise training could attenuate diabetic renal injury via regulating endogenous hydrogen sulfide (H2 S) production. First, C57BL/6 mice were allocated into the control, diabetes, exercise, and diabetes + exercise groups. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). Treadmill exercise continued for four weeks. Second, mice was allocated into the control...
#1Thoru Pederson (UMMS: University of Massachusetts Medical School)H-Index: 65
#1Faye Chleilat (U of C: University of Calgary)H-Index: 4
#2Alana Schick (U of C: University of Calgary)H-Index: 6
Last. Raylene A. Reimer (U of C: University of Calgary)H-Index: 42
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Mounting evidence demonstrates that paternal diet programs offspring metabolism. However, the contribution of a pre-conception paternal high protein (HP) diet to offspring metabolism, gut microbiota, and epigenetic changes remains unclear. Here we show that paternal HP intake in Sprague Dawley rats programs protective metabolic outcomes in offspring. Compared to paternal high fat/sucrose (HF/S), HP diet improved body composition and insulin sensitivity and improved circulating satiety hormones a...
#1Jonathan Gagnon (UdeM: Université de Montréal)H-Index: 2
#2Véronique CaronH-Index: 6
Last. André J. TremblayH-Index: 26
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Neuron-derived orphan receptor 1, NR4A3 (Nor1)/NR4A3 is an orphan nuclear receptor involved in the transcriptional control of developmental and neurological functions. Oxidative stress-induced conditions are primarily associated with neurological defects in humans, yet the impact on Nor1-mediated transcription of neuronal genes remains with unknown mechanism. Here, we demonstrate that Nor1 is a non-conventional target of SUMO2/3 conjugation at Lys-137 contained in an atypic ψKxSP motif referred ...
#1Mohammad Asad (IICB: Indian Institute of Chemical Biology)H-Index: 2
#2Abdus Sabur (University of Gour Banga)
Last. Nahid Ali (IICB: Indian Institute of Chemical Biology)H-Index: 33
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Visceral leishmaniasis (VL) is a debilitating human pathogenesis in which the body's immune functions are severely compromised. Various subsets of T cells, including Th17 cells are important regulators of immune responses observed in various pathologies. The role of Th17 cells and its correlation with immuno-regulatory cytokines are however not well understood in human VL. Herein we studied how IL-17 is associated with the progression of Leishmania donovani infection using murine model of VL. We...
Top fields of study
Diabetes mellitus
Cell biology