Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer’s Disease in Patients with Mild Cognitive Impairment – A Multicenter DTI and Volumetry Study

Background: Hippocampal grey matter (GM) atrophy predicts conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Pilot data suggests that mean diffusivity (MD) in the hippocampus, as measured with diffusion tensor imaging (DTI), may be a more accurate predictor of conversion than hippocampus volume. In addition, previous studies suggest that volume of the cholinergic basal forebrain may reach a diagnostic accuracy superior...