Background null Italy has one of the oldest populations in the World and more than one million dementia cases can be estimated at the national level. null Objective null The objectives of this national survey include: 1) to report the administrative features and the professional competencies of Centers for Cognitive Disorders and Dementias (CCDDs); 2) to document possible discrepancies by geographic macro-area; and 3) to identify the features of CCDDs that are associated with a better quality in...
Last. Clinton B. Wright(NIH: National Institutes of Health)H-Index: 59
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BACKGROUND Meta-analyses of individuals' cognitive data are increasing to investigate the biomedical, lifestyle, and sociocultural factors that influence cognitive decline and dementia risk. Pre-statistical harmonization of cognitive instruments is a critical methodological step for accurate cognitive data harmonization, yet specific approaches for this process are unclear. OBJECTIVE To describe pre-statistical harmonization of cognitive instruments for an individual-level meta-analysis in the b...
Last. Anne M. Murray(UMN: University of Minnesota)H-Index: 44
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BACKGROUND Chronic kidney disease (CKD), a growing public health issue in the elderly, is associated with increased risk of cognitive impairment. OBJECTIVE To investigate the mechanisms through which CKD impacts brain health using longitudinal imaging. METHODS We identified 97 participants (74 CKD and 23 non-CKD) from the BRINK (BRain IN Kidney Disease), a longitudinal study of CKD with two MRI scans (baseline and 3-year follow-up). We measured the associations between baseline and change in kid...
BACKGROUND Many cases of dementia with Lewy bodies (DLB) present with various psychotic features, including hallucinations, depression, catatonia, and delusions before the onset of cognitive impairment. However, the characteristic features of these psychotic symptoms in prodromal DLB have not been sufficiently described. OBJECTIVE To clarify and describe the psychotic features of prodromal DLB before overt cognitive impairment. METHODS The authors analyzed the characteristic psychotic features o...
#2Dimitri Van De Ville(EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 47
Last. Alessandra Griffa(EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 23
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Background null Alzheimer's disease (AD) pathology impacts the response to treatment in patients with idiopathic normal pressure hydrocephalus (iNPH), possibly through changes in resting-state functional connectivity (rs-FC). null Objective null To explore the relationship between cerebrospinal fluid biomarkers of AD and the default mode network (DMN)/hippocampal rs-FC, in iNPH patients based on their outcome after cerebrospinal fluid tap test (CSFTT), and in patients with AD. null Methods null ...
#1Jing-jing Zhang(WUST: Wuhan University of Science and Technology)
#2Lin Li(WUST: Wuhan University of Science and Technology)
Last. Ya-fu Yu(WUST: Wuhan University of Science and Technology)
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BACKGROUND Some studies have demonstrated an association between low and high body mass index (BMI) and an increased risk of dementia. However, only a few of these studies were performed in rural areas. OBJECTIVE This cross-sectional study investigated the associations between BMI and cognitive impairment among community-dwelling older adults from rural and urban areas. METHODS 8,221 older persons enrolled in the Hubei Memory & Ageing Cohort Study (HMACS) were recruited. Sociodemographic and lif...
Background null Vascular pathology is a common feature in patients with advanced Alzheimer's disease, with cerebral amyloid angiopathy (CAA) and microvascular changes commonly observed at autopsies and in genetic mouse models. However, despite a plethora of studies addressing the possible impact of CAA on brain vasculature, results have remained contradictory, showing reduced, unchanged, or even increased capillary densities in human and rodent brains overexpressing amyloid-β in Alzheimer's dise...
#1Nikki L. Hill(PSU: Pennsylvania State University)H-Index: 12
#2Sakshi Bhargava(PSU: Pennsylvania State University)H-Index: 5
Last. Jacqueline Mogle(PSU: Pennsylvania State University)H-Index: 21
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Background null Subjective cognitive decline (SCD) may be an early indicator of cognitive impairment, but depressive symptoms can confound this relationship. Associations may be influenced by differences between individuals (i.e., between-persons) or how each individual changes in their experiences over time (i.e., within-persons). null Objective null We examined depressive symptoms as a mediator of the between- and within-person associations of SCD and objective memory in older adults. null Met...
BACKGROUND Insomnia is associated with worsened clinical outcomes among Alzheimer's disease dementia (AD) patients, increased caregiver burden, and healthcare utilization. OBJECTIVE This study aimed to characterize the incremental healthcare burden of insomnia in AD using real-world data. METHODS A retrospective observational study was conducted on AD patients selected from the IBM® MarketScan Commercial and Medicare Supplemental Databases. AD patients with claims-based evidence of insomnia were...