Cost of prostate image-guided radiation therapy: results of a randomized trial.

Published on Jan 1, 2013in Radiotherapy and Oncology4.856
· DOI :10.1016/J.RADONC.2012.11.011
Lionel Perrier14
Estimated H-index: 14
Magali Morelle14
Estimated H-index: 14
+ 13 AuthorsRenaud de Crevoisier28
Estimated H-index: 28
(French Institute of Health and Medical Research)
Abstract Purpose This cost analysis aimed to quantify the cost of IGRT in relation to IGRT frequency and modality with Cone Beam Computed Tomography (CBCT) or orthogonal electronic portal imaging with fiducial markers (EPI-FM). Material and methods Patients undergoing IGRT for localized prostate cancer were randomized into two prostate control frequencies (daily or weekly). Costs were calculated based on the micro-costing results according to hospitals' perspectives (in Euros, 2009) and the time horizon was radiation therapy. Results A total of 208 patients were enrolled in seven French cancer centers. A total of 6865 fractions were individually analyzed. The mean total treatment fraction duration was 21.0min for daily CBCT and 18.3min for daily EPI-FM. Increasing the control frequency from weekly to daily increased the mean treatment fraction duration by 7.3min (+53%) for CBCT and 1.7min (+10%) for EPI-FM ( p ⩽0.01). The mean additional cost per patient of daily controls compared with weekly controls was €679 and €187 for CBCT and EPI-FM, respectively ( p Conclusions The incremental costs due to different prostate IGRT strategies are relatively moderate, suggesting that daily IGRT combined with intensity-modulated RT (IMRT) could be administered in cases of high-dose radiation delivery to the prostate.
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