Radiotherapy and Oncology
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#1C. Tang (University of Manchester)
#2Hitesh Mistry (University of Manchester)H-Index: 14
Last. Ahmed Salem (University of Manchester)H-Index: 35
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Abstract Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.
#1R.L. Hachadorian (Dartmouth College)H-Index: 2
Last. Lesley A. Jarvis (Dartmouth–Hitchcock Medical Center)H-Index: 15
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PURPOSE In mono-isocentric radiation therapy treatment plans designed to treat the whole breastand supraclavicular lymph nodes, the fields meet at isocenter, forming the match line. Insufficient coverage at the match line can lead to recurrence and overlap over weeks of treatment can lead to increased risk of healthy tissue toxicity. Cherenkov imaging was used to assess the accuracy of delivery at the match line and identify potential incidents during patient treatments. METHODS AND MATERIALS A ...
#1Farnoush Forghani (University of Colorado Denver)
#2Taylor Patton (University of Colorado Denver)
Last. Yevgeniy Vinogradskiy (University of Colorado Denver)H-Index: 16
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Abstract This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation- coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.
#1Matthew D. La Fontaine (NKI-AVL: Netherlands Cancer Institute)H-Index: 4
#2N.M. Bruin (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
Last. Jan-Jakob Sonke (NKI-AVL: Netherlands Cancer Institute)H-Index: 55
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Abstract Purpose to test if the relative change in FDG-PET SUVmax over the course of treatment was associated with disease progression and overall survival. Additionally, the prognostic values of other first-order PET-metric changes were investigated. Methods The study included 38 patients with stage II-III NSCLC, who underwent concurrent chemoradiotherapy. Patients received two pre-treatment FDG-PET scans and four during-treatment scans at weekly intervals. SUVmax was normalized to the start of...
#1Yan Huang (Southern Medical University)H-Index: 1
#2Hailong Sheng (Southern Medical University)H-Index: 1
Last. Jingyuan Sun (Southern Medical University)H-Index: 4
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Abstract null null Background and purpose null Radiotherapy (RT) has a promising anti-tumor effect depending on its effects on both cancer cells and tumor immune microenvironment (TIME). As one of the most common alterations in hepatocellular carcinoma (HCC), wnt/β-catenin pathway activation, has been reported to induce radioresistance and suppressive TIME. In this study, we aim to explore the effect of wnt/β-catenin inhibitor ICG-001 on radiosensitivity and RT-related TIME of HCC and the underl...
#1Waqar Haque (Houston Methodist Hospital)H-Index: 17
#2Anukriti Singh (Rice University)
Last. Andrew M. Farach (Houston Methodist Hospital)H-Index: 8
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Abstract null null PURPOSE null The utility of post-mastectomy radiotherapy (PMRT) in women with a nodal complete response (CRn) to neoadjuvant chemotherapy (NAC) is unknown. NSABP B-51 is evaluating this question, but has not reported results thus far. Therefore, we sought to answer this question with the National Cancer Database. null null null METHODS null The National Cancer Database was queried for women with cT1-4N1-3M0 breast cancer who had undergone NAC and were ypN0 at mastectomy. Stati...
#1V. Groen (UU: Utrecht University)H-Index: 1
#2Nicolaas P.A. Zuithoff (UU: Utrecht University)H-Index: 28
Last. Karin Haustermans (Katholieke Universiteit Leuven)H-Index: 74
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BACKGROUND AND PURPOSE The phase III FLAME trial (NCT01168479) showed an increase in five-year biochemical disease-free survival, with no significant increase in toxicity when adding a focal boost to external beam radiotherapy (EBRT) for localized prostate cancer [Kerkmeijer et al. JCO 2021]. The aim of this study was to investigate the association between delivered radiation dose to the anorectum and gastrointestinal (GI) toxicity (grade ≥2). MATERIAL AND METHODS All patients in the FLAME trial...
#1Philippa Johnstone (University of Oxford)
#2Leroy Okonta (The Royal Marsden NHS Foundation Trust)
Last. Mark Wing
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Abstract null null Background and purpose null Locally recurrent rectal cancer (LRRC) is associated with considerable morbidity, poor quality of life and an overall survival of 9 months. The non-operative treatment of LRRC is an understudied area, there is no consensus on management in this setting. null We aim to perform a retrospective, multicentre analysis of patients treated with SABR reirradiation. null null null Materials and methods null All patients were identified who received SABR re-i...
#1Xue-Song Sun (SYSU: Sun Yat-sen University)H-Index: 3
#2Si-Yi Xie (SYSU: Sun Yat-sen University)
Last. Hai-Qiang Mai (SYSU: Sun Yat-sen University)H-Index: 13
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BACKGROUND We aimed to compare the survival outcomes of patients with nasopharyngeal carcinoma (NPC) who had different smoking behaviors and were treated with two- or three-dimensional radiotherapy (2D/3DRT) or intensity-modulated radiotherapy (IMRT) with a long-term follow up. METHODS From 1990 to 2016, 23,325 patients with NPC were included. The primary endpoint of this study was overall survival (OS). The log-rank test and Cox proportional hazards regression model were used to assess the pati...
#2Thomas Eade (RNSH: Royal North Shore Hospital)H-Index: 27
Last. Thomas P. ShakespeareH-Index: 20
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Abstract null null Purpose null The five grade group system has been validated for men treated with radical prostatectomy. However, the prognostic value for men treated with radiation therapy is uncertain, with prior studies utilising old techniques and doses. We aimed to validate the ISUP groupings for men treated with contemporary radiation therapy. null null null Methods null Men with localised prostate cancer treated with image-guided, dose-escalated (≥78Gy) external beam radiation were iden...
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