Renaud de Crevoisier
University of Rennes
CancerInternal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyArtificial intelligenceImage registrationPattern recognitionProstateProstate cancerRectumPopulationNuclear medicineComputer visionComputer scienceRadiation therapyMedicineImage-guided radiation therapy
Publications 138
#1Zine-Eddine Khene (University of Rennes)H-Index: 8
#2Romain KokorianH-Index: 1
Last. Karim Bensalah (University of Rennes)H-Index: 64
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INTRODUCTION To evaluate the value of image-based texture analysis for predicting progression-free survival (PFS) and overall survival (OS) in patients with metastatic clear cell renal carcinoma (cCCR) treated with nivolumab. METHODS This retrospective study included 48 patients with metastatic cCCR treated with nivolumab. Nivolumab was used as a second- or third-line monotherapy. Texture analysis of metastatic lesions was performed on CT scanners obtained within 1 month before treatment. Textur...
#1Gwenaelle CreffH-Index: 1
#2Franck JegouxH-Index: 16
Last. Renaud de CrevoisierH-Index: 28
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#1Martin A. Ebert (SCGH: Sir Charles Gairdner Hospital)H-Index: 26
#2Sarah L. Gulliford (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 23
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
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For decades, dose-volume information for segmented anatomy has provided the essential data for correlating radiotherapy dosimetry with treatment-induced complications. Dose-volume information has formed the basis for modelling those associations via normal tissue complication (NTCP) models and for driving treatment planning. Limitations to this approach have been identified. Many studies have emerged demonstrating that the incorporation of information describing the spatial nature of the dose di...
#1Jonathan KhalifaH-Index: 11
#2Stéphane SupiotH-Index: 29
Last. Olivier RiouH-Index: 7
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Abstract null null Purpose null Curative radio-chemotherapy is recognized as a standard treatment option for muscle-invasive bladder cancer (MIBC). Nevertheless, the technical aspects for MIBC radiotherapy are heterogeneous with a lack of practical recommendations. null null null Methods and Materials null In 2018, a workshop identified the need for two cooperative groups to develop consistent, evidence-based guidelines for irradiation technique in the delivery of curative radiotherapy. Two radi...
1 CitationsSource
#2Pierre FontaineH-Index: 3
Last. Oscar AcostaH-Index: 21
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In prostate cancer radiotherapy, biochemical recurrence has been traditionally predicted using radiomics approaches with however limited performance. The purpose of this work was to use a mechanistic in silico model of tumor growth and response to irradiation to obtain better predictions. A cohort of 76 patients with localized prostate adenocarcinoma having undergone external beam radiotherapy was used. Analogous digital tissues were built from pre-treatment MRI. The prescribed irradiation proto...
#2A. BarateauH-Index: 5
Last. Oscar AcostaH-Index: 21
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Several approaches have been proposed to generate pseudo computed tomography (pCT) from MR images for radiotherapy dose calculation. Quantification of errors in pCT has been reported using global scores disregarding spatial heterogeneity. The aim of this work was to propose a population voxel-based workflow allowing the local assessment of errors in the generation of pCTs from MRI. For the voxel-wise analysis to be anatomically meaningful, a robust customized inter-patient non-rigid registration...
OBJECTIVE Purposes of this work were i) to develop an in silico model of tumor response to radiotherapy, ii) to perform an exhaustive sensitivity analysis in order to iii) propose a simplified version and iv) to predict biochemical recurrence with both the comprehensive and the reduced model. METHODS A multiscale computational model of tumor response to radiotherapy was developed. It integrated the following radiobiological mechanisms: oxygenation, including hypoxic death; division of tumor cell...
1 CitationsSource
#1Eugenia Mylona (French Institute of Health and Medical Research)H-Index: 4
#2Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
Last. Renaud de Crevoisier (French Institute of Health and Medical Research)H-Index: 28
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Abstract Purpose /Objectives: Recent voxel-based studies have shown that the dose to specific rectal and urethro-vesical subregions is predictive of toxicities, following prostate cancer IMRT. The objective of this study was to validate the discriminatory power of these subregions with respect to the whole organs, in a large independent population. Material/Methods The validation cohort consisted of 450 patients, from the XXX(BLIND) trial, treated with 3D-CRT at 66-74 Gy. Previous voxel-based an...
4 CitationsSource
#1Pierre FontaineH-Index: 3
#2Oscar Acosta (French Institute of Health and Medical Research)H-Index: 21
Last. Adrien Depeursinge (University of Applied Sciences Western Switzerland)H-Index: 26
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In standard radiomics studies the features extracted from clinical images are mostly quantified with simple statistics such as the average or variance per Region of Interest (ROI). Such approaches may smooth out any intra-region heterogeneity and thus hide some tumor aggressiveness that may hamper predictions. In this paper we study the importance of feature aggregation within the standard radiomics workflow, which allows to take into account intra-region variations. Feature aggregation methods ...
1 CitationsSource