Five Year Results of a Randomized External Beam Radiotherapy Hypofractionation Trial for Prostate Cancer

Based on the assumption that the α/β ratio for prostate cancer is low at 1.5 Gy, a randomized trial was devised with a dose escalation strategy. We hypothesized that using hypofractionation to deliver the equivalent of an 8 Gy difference in 2 Gy fractions would significantly improve biochemical failure (BF) without increasing bladder or rectal side effects. The trial compared 76 Gy in conventional 2.0 Gy fractions (CIMRT) to 70.2 Gy in 2.7 Gy...