Alan Pollack
University of Miami
CancerInternal medicineRadiologyUrologySurgeryPathologyOncologyRandomized controlled trialIn vivoExternal beam radiotherapyBiopsyProstateAndrogenProstatectomyProstate cancerProstate-specific antigenNuclear medicineCancer researchProportional hazards modelRadiation therapyMedicine
578Publications
85H-index
18.5kCitations
Publications 580
Newest
Purpose/Objective(s) null Genomic classification (GC) in prostate cancer has demonstrated ability to distinguish patients with favorable disease from those most at risk of metastasis and cancer-related death. GC contributes to personalization of care by identifying subsets of patients for whom treatment intensification with radiation and hormonal therapy may be warranted. In treatment-naive patients, risk stratification by standard clinical pathologic factors and GC can be influenced by sampling...
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#1W. Ma (UM: University of Miami)
#2Wensi Tao (UM: University of Miami)H-Index: 1
Last. Alan Pollack (UM: University of Miami)H-Index: 85
view all 8 authors...
Purpose/objective(s) null Aberrant epigenetic modifications play an important role in prostate cancer development and progression. Histone deacetylase inhibitors (HDACi) are a novel class of small-molecular compounds that have been shown to have activity in several tumor types. Some HDACi's induce a stress response that affects DNA damage repair (radiosensitization) and androgen receptor (AR) signaling (increased sensitivity to androgen blockage). We hypothesized that the HDACi, romidepsin, woul...
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#1Paul L. Nguyen (Brigham and Women's Hospital)H-Index: 73
#2Huei-Chung HuangH-Index: 3
Last. M. Roach (UCSF: University of California, San Francisco)H-Index: 15
view all 20 authors...
PURPOSE/OBJECTIVE(S) Decipher is a prognostic 22-gene genomic classifier (GC) prospectively validated post-prostatectomy. Herein, we validate the performance of the GC in pre-treatment biopsy samples within the context of three randomized phase III high-risk definitive radiotherapy trials. MATERIALS/METHODS Following a pre-specified and approved CTEP-CCSC analysis plan (NRG-GU-TS006), we obtained all available formalin-fixed paraffin-embedded tissue from biopsy specimens from the NRG biobank fro...
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#1Amin Hayee (UM: University of Miami)H-Index: 1
#2Isabella Lugo (UM: University of Miami)H-Index: 1
Last. Oleksandr N. Kryvenko (UM: University of Miami)H-Index: 22
view all 15 authors...
CONTEXT.— Effect of tumor nodule (TN) location in the prostate on adverse radical prostatectomy (RP) outcomes is not well studied in contemporary cohort. OBJECTIVE.— To investigate the significance of TN location with respect to extraprostatic extension (EPE), seminal vesicle invasion (SV+), and positive margin status (SM+) in 1388 RPs. DESIGN.— Each TN at RP was independently graded, staged, and volumetrically assessed. TNs with at least 80% of their volume occupying either the anterior or post...
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#1Oleksii A. Iakymenko (UM: University of Miami)H-Index: 2
#2Isabella Lugo (UM: University of Miami)H-Index: 1
Last. Merce Jorda (UM: University of Miami)H-Index: 32
view all 12 authors...
BACKGROUND Increasing percentages of Gleason pattern 4 (GP4%) in radical prostatectomy (RP) correlate with an increased likelihood of nonorgan-confined disease and earlier biochemical recurrence (BCR). However, there are no detailed RP studies assessing the impact of GP4% and corresponding tumor volume (TV) on extraprostatic extension (EPE), seminal vesicle (SV) invasion (SV+), and positive surgical margin (SM) status (SM+). METHODS In 1301 consecutive RPs, we analyzed each tumor nodule (TN) for...
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#1Daiki Hara (UM: University of Miami)H-Index: 2
#2Wensi Tao (UM: University of Miami)H-Index: 1
Last. Alan Pollack (UM: University of Miami)H-Index: 85
view all 8 authors...
Abstract Purpose Gold nanoparticle (GNP) as a promising theranostic probe has been increasingly studied. The tumor-targeting efficiency of GNPs is crucial to increase the therapeutic ratio. In this study, we developed PSMA-targeted GNPs to enhance GNP uptake in prostate cancer and developed an x-ray fluorescence imaging system to noninvasively monitor and assess GNP delivery. Materials and Methods For targeted therapy of prostate cancer, anti-prostate-specific membrane antigen (PSMA) antibodies ...
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#2Nellie Brovold (HFHS: Henry Ford Health System)H-Index: 1
#10Matthew C. Abramowitz (UM: University of Miami)H-Index: 14
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#1Nishwant Swami (UMMS: University of Massachusetts Medical School)H-Index: 1
#2William L. Hwang (Harvard University)H-Index: 20
Last. Alan Dal Pra (UM: University of Miami)H-Index: 18
view all 29 authors...
Abstract null null Background: High tumor mutation burden (TMB) and total mutation count (TMC) can be predictive of better response to immune checkpoint blockade (ICB). Nevertheless, TMB and TMC are limited by variation across cancers and inconsistent definitions due to different profiling methods (targeted vs whole genome sequencing). Our objective was to identify genomic alterations (GAs) associated with ICB response and builds a novel genomic signature predictive of ICB response, independent ...
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#1Shauna R. Campbell (Cleveland Clinic)H-Index: 5
#2M.C. Tom (Baptist Hospital of Miami)H-Index: 4
Last. Rahul D. Tendulkar (Cleveland Clinic)H-Index: 21
view all 13 authors...
BACKGROUND Salvage radiotherapy (SRT) is an established treatment for men with biochemical recurrence following radical prostatectomy (RP). There are several risk factors associated with adverse outcomes; however, the value of postoperative prostate-specific antigen (PSA) kinetics is less clear in the ultrasensitive PSA era. OBJECTIVE To characterize the impact of PSA kinetics on outcomes following SRT and generate nomograms to aid in identifying patients with an increased risk of adverse clinic...
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