Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF‐1α release and compatible structural support
Abstract
Without chemotactic cues and structural support, cavitary brain lesions typically fail to recruit endogenous neural progenitor cells (NPCs). Toward resolving this, we engineered multifunctional biomaterials comprising injectable gelatin-hydroxyphenylpropionic acid (Gtn-HPA) hydrogels and dextran sulfate/chitosan polyelectrolyte complex nanoparticles (PCNs) that delivered stromal cell-derived factor-1α (SDF-1α). Over 7 d of interface with in...
Paper Details
Title
Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF‐1α release and compatible structural support
Published Date
Nov 27, 2012
Journal
Volume
27
Issue
3
Pages
1023 - 1033
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