Myron Spector
Brigham and Women's Hospital
AnatomyActinBiomedical engineeringPathologyGlycosaminoglycanRegeneration (biology)ChemistryExtracellular matrixMaterials scienceMesenchymal stem cellIn vitroCartilageType II collagenChondrocyteImplantChondrogenesisTissue engineeringMedicineScaffoldCell biology
Publications 332
#1Christopher J. Love (MIT: Massachusetts Institute of Technology)
#2Daniel Kirschenbaum (UZH: University of Zurich)H-Index: 6
Last. Adriano Aguzzi (UZH: University of Zurich)H-Index: 111
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Background and Purpose: The classic presentation of chronic (stage III) hemorrhagic stroke lesions is a fluid-filled cavity. In one of the most commonly used animal models of intracerebral hemorrha...
#1Wanting NiuH-Index: 3
#2Teck Chuan LimH-Index: 9
Last. Myron SpectorH-Index: 67
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Bone marrow mesenchymal stem cells (bMSCs) are responsible in the repair of injured tissue through differentiation into multiple cell types and secretion of paracrine factors, and thus have a broad application profile in tissue engineering/regenerative medicine, especially for the musculoskeletal system. The lesion due to injury or disease may be a closed irregular-shaped cavity deep within tissue necessitating an injectable biomaterial permissive of host (endogenous) cell migration, proliferati...
#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti SinghH-Index: 14
Last. Michael J. YoungH-Index: 43
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#1Myron Spector (Brigham and Women's Hospital)H-Index: 67
#1Abdulmonem Alshihri (KSU: King Saud University)H-Index: 8
#2Wanting Niu (Brigham and Women's Hospital)H-Index: 3
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
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The treatment of a variety of defects in bony sites could benefit from mitogenic stimulation of osteoprogenitor cells, including endogenous bone marrow-derived mesenchymal stem cells (bMSCs), and from provision of such cells with a matrix permissive of their migration, proliferation, and osteogenic differentiation. That such MSC stimulation could result from treatment with noninvasive (extracorporeal) shock waves (ESWs), and the matrix delivered by injection could enable this therapeutic approac...
2 CitationsSource
1 Citations
#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti Singh (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 14
Last. Michael J. Young (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 43
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Abstract Many progenitor and stem cell-based therapies in pre-clinical development and in clinical trial have failed to achieve desired outcomes, in part, due to: low cell viability; dispersion of cells from the injection site; and/or failure of the cells to differentiate and engraft into host tissue. These problems may be exacerbated by the elevated shear stress applied to the cells as they pass through a small-bore needle. Our supposition is that these issues can be mitigated by replacing the ...
1 CitationsSource
#1Teck Chuan Lim (MIT: Massachusetts Institute of Technology)H-Index: 9
#2Emiri T. Mandeville (Harvard University)H-Index: 20
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
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We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of ast...
6 CitationsSource
#1Ravikumar Rajappa (Brigham and Women's Hospital)H-Index: 1
#2Mark R. Nazal (Harvard University)H-Index: 3
Last. Scot T. MartinH-Index: 50
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The purpose of this study was to evaluate the histologic features of the caprine labrum, with emphasis on the chondrolabral junction, with the goal of informing the feasibility of the goat as an animal model. The left hip joint of six adolescent Spanish goats (Capra pyrenaica) was harvested and subjected to anatomical and histological assessments. Human acetabular and femoral head samples, collected during total hip arthroplasty, served as comparison samples. The caprine labrum was found to cons...
1 CitationsSource
#1Myron Spector (VA Boston Healthcare System)H-Index: 67
1 CitationsSource
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