Whole-Exome Sequencing Studies of Nonhereditary (Sporadic) Parathyroid Adenomas

Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in <50% of nonhereditary (sporadic) parathyroid adenomas. To identify genetic abnormalities in nonhereditary parathyroid adenomas by whole-exome sequence analysis. Whole-exome sequence analysis was performed on parathyroid adenomas and leukocyte DNA samples from 16 postmenopausal women without a family history of parathyroid...