The Journal of Clinical Endocrinology and Metabolism
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#1Komal Waqas (Erasmus University Medical Center)H-Index: 1
#2Jinluan Chen (Erasmus University Medical Center)H-Index: 2
Last. M. Carola Zillikens (Erasmus University Medical Center)H-Index: 16
view all 7 authors...
Background null Accumulation of advanced glycation end-products (AGEs) in skeletal muscle has been implicated in development of sarcopenia. null Aim null To obtain further insight in the pathophysiology of sarcopenia we studied its relationship with skin AGEs in the general population. null Methods null In a cross-sectional analysis, 2744 participants of Northern European background, mean age 74.1 years were included from the Rotterdam Study. Skin AGEs were measured using AGE readerTMas Skin aut...
#1Dan Shan (Sichuan University)H-Index: 1
#2Jinbiao Han (Sichuan University)
Last. Yongchun Shen (Sichuan University)H-Index: 17
view all 6 authors...
OBJECTIVE Polycystic ovary syndrome (PCOS) is a highly heritable disease. Emerging evidence elucidated the elevated prevalence of reproductive abnormalities in first-degree relatives (FDRs) of patients with PCOS. METHODS Ten databases were searched in December 2020 (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials,, CBM, CNKI, VIP and WanFang and WHO international clinical trials registry platform). This study included cohort, case-control, or cro...
#1Priyanka Singh (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 7
#2Sanjay Kumar Bhadada (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 25
Last. Sudhaker D Rao (HFH: Henry Ford Hospital)H-Index: 14
view all 9 authors...
STUDY DESIGN Primary hyperparathyroidism (PHPT) results from the hypersecretion of parathyroid hormone from parathyroid tumors. Transcription factor i.e. Paired box1 (PAX1) is active in the parathyroid gland development. In the present study, we analyzed the role of DNA methylation via bisulphite specific polymerase chain reaction (BSP) and histone modifications via chromatin immunoprecipitation (ChIP) in regulating the differential expression of PAX1 in parathyroid adenomas tissues. RESULTS The...
#1Yi Wang (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Fengjiang Sun (JNU: Jinan University)H-Index: 2
Last. Ying Wen (CDC: Centers for Disease Control and Prevention)H-Index: 4
view all 18 authors...
CONTEXT While the associations between thyroid markers and gestational diabetes mellitus (GDM) have been extensively studied, the results are inconclusive and the mechanisms remain unclear. OBJECTIVE We aimed to investigate the prospective associations of thyroid markers in early gestation with GDM risk, and examine the mediating effects through lipid species. METHODS This study included 6068 pregnant women from the Tongji-Shuangliu Birth Cohort. Maternal serum thyroid markers (free triiodothyro...
#1Martha Hanschkow (Leipzig University)H-Index: 1
#2Nathalie Boulet (University of Toulouse)H-Index: 8
Last. Kathrin Landgraf (Leipzig University)H-Index: 15
view all 8 authors...
Context null MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. null Objective null With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and rela...
#1Chaojie Ye (SJTU: Shanghai Jiao Tong University)
#2Lijie Kong (SJTU: Shanghai Jiao Tong University)
Last. Yiping Xu (SJTU: Shanghai Jiao Tong University)H-Index: 3
view all 15 authors...
Purpose null Observational studies have associated obesity with chronic kidney disease (CKD) and arterial stiffness, but the causality remains unclear. We aimed to investigate the causality of obesity with CKD and arterial stiffness using Mendelian randomization (MR) analysis. null Methods null We genotyped 14 body mass index (BMI)-associated variants validated in East Asians in 11384 Chinese adults. A genetic risk score based on the 14 variants and the 14 individual single nucleotide polymorphi...
#1Christin Volk (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 1
#2Benjamin Schmidt (MLU: Martin Luther University of Halle-Wittenberg)
Last. Gabriele I. Stangl (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 34
view all 9 authors...
CONTEXT Hyperphosphatemia and high levels of fibroblast growth factor 23 (FGF23) are risk factors for cardiovascular events in patients with chronic kidney diseases. However, the impact of an inorganic phosphorus additive in healthy people is largely unknown. OBJECTIVE To investigate the acute effect of excessive dietary phosphorus administered as sodium-dihydrogen phosphate on the postprandial levels of Pi and FGF23 and the response to food. DESIGN Double-blind placebo-controlled crossover stud...
#1Panpan He (Southern Medical University)H-Index: 2
#2Huan Li (Southern Medical University)H-Index: 3
Last. Xianhui Qin (Southern Medical University)H-Index: 26
view all 9 authors...
AIMS We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. MATERIALS AND METHODS 16,257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose ≥7.0 mmol/L or glycated hemoglobin ≥6.5% during ...
#1Jun Mori (Kyoto Prefectural University of Medicine)H-Index: 16
#2Atsushi Umemura (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Tomohiro Chiyonobu (Kyoto Prefectural University of Medicine)H-Index: 16
view all 7 authors...
Context null Nonalcoholic fatty liver disease (NAFLD) is becoming a major issue worldwide, even in children. Multiple parallel hits hypothesis has been suggested as progress of NAFLD, but the mechanism of NAFLD is not completely understood. β-Tubulin is essential in mitoses, neuronal migration, and axon guidance during neuronal development. Pathogenic variants in the TUBB3 gene were shown to be associated with a wide spectrum of neurological abnormalities, but not accompanied with hepatic compli...
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Context (language use)
Diabetes mellitus