The Journal of Clinical Endocrinology and Metabolism
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#1Kuan-Yu ChenH-Index: 2
#2Shin-Yu Lin (NTU: National Taiwan University)H-Index: 14
Last. Hung-Yuan Li (NTU: National Taiwan University)H-Index: 23
view all 13 authors...
BACKGROUND Maternal lipids during pregnancy and placental growth factors are associated with excess foetal growth. However, how these factors interact to increase the risk of delivering large-for-gestational-age (LGA) neonates remains unclear. In this study, we investigated the relationship between maternal plasma triglyceride (TG) and free fatty acids (FAs) during pregnancy, cord blood insulin-like growth factors (IGF) and LGA. In a cell model, we studied the effect of different FAs on placenta...
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Until recently, weight loss in the elderly obese was feared due to ensuing muscle loss and frailty. Facing overall increasing longevity, high rates of obesity in older subjects (≥65 years) and a growing recognition of the health and functional cost of the number of obesity years, abetted by evidence that intentional weight loss in older obese subjects is safe, this approach is gradually, but not unanimously, being replaced by more active principles. Lifestyle interventions that include reduced b...
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#1Martine PaquetteH-Index: 10
#2Julie Amyot (MHI: Montreal Heart Institute)H-Index: 1
Last. Sophie BernardH-Index: 12
view all 5 authors...
CONTEXT Severe hypertriglyceridemia (fasting triglycerides (TG) concentration ≥ 10 mmol/L) can be caused by multifactorial chylomicronemia syndrome (MCS) or familial chylomicronemia syndrome (FCS). Both conditions are associated with an increased risk of acute pancreatitis. The clinical differences between MCS patients with or without a rare variant in TG-related genes have never been studied. OBJECTIVES To compare the clinical and biochemical characteristics of FCS, positive-MCS patients and ne...
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#1Jie Min (HUST: Huazhong University of Science and Technology)H-Index: 5
#1Jie Min (HUST: Huazhong University of Science and Technology)
Last. Slavica Tudzarova (UCLA: University of California, Los Angeles)H-Index: 10
view all 6 authors...
Diabetic retinopathy (DR) is the leading cause of blindness in adults of developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal impairment preceding microvascular abnormalities, which is often underappreciated in the clinic. Most current therapeutic strategies, including anti-vascular endothelial growth factor (anti-VEGF)- antibodies, aim at treating the advanced stages (diabetic macular oedema and proliferative diabetic re...
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#1Karol M. Pencina (Brigham and Women's Hospital)H-Index: 21
#2Arthur L. Burnett (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 71
Last. Shalender Bhasin (Brigham and Women's Hospital)H-Index: 91
view all 11 authors...
BACKGROUND Androgen deficiency is common among prostate cancer survivors, but many guidelines consider history of prostate cancer a contraindication for testosterone replacement. We determined the safety and efficacy of a selective androgen receptor modulator (OPK-88004) in symptomatic, testosterone-deficient men who had undergone radical prostatectomy for low grade, organ-confined prostate cancer. METHODS In this placebo-controlled, randomized, double-blind trial, 114 men, >19 years, who had un...
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#1Ping Hu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Xiuyi Chen (HUST: Huazhong University of Science and Technology)
Last. An Pan (HUST: Huazhong University of Science and Technology)H-Index: 65
view all 19 authors...
AIMS We aimed to assess the association between gut bacterial biomarkers during early pregnancy and subsequent risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. METHODS Within the Tongji-Shuangliu Birth Cohort study, we conducted a nested case-control study among 201 incident GDM cases and 201 matched controls. Fecal samples were collected during early pregnancy (at 6-15 weeks), and GDM was diagnosed at 24-28 weeks of pregnancy. Community DNA isolated from fecal samples and ...
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#1Charles D Nicoli (UVM: University of Vermont)H-Index: 1
#2April P. Carson (UAB: University of Alabama at Birmingham)H-Index: 26
Last. Mary Cushman (UVM: University of Vermont)H-Index: 110
view all 7 authors...
CONTEXT The peptide neurotensin is implicated in insulin resistance, diabetes mellitus (DM), and cardiovascular disease. OBJECTIVE We studied the association of neurotensin's stable precursor, pro-neurotensin/neuromedin N (pro-NT/NMN) with incident metabolic syndrome (MetS) and DM. DESIGN/SETTING/PARTICIPANTS We included 3,772 participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study who completed the baseline exam (2003-2007), the follow-up exam (2013-2016), ...
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#1Helen B Chin (GMU: George Mason University)
#2Andrea Kelly (UPenn: University of Pennsylvania)H-Index: 31
Last. David M. Umbach (NIH: National Institutes of Health)H-Index: 51
view all 16 authors...
CONTEXT Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established. OBJECTIVE To assess the association between infant feeding practice and longitudinally measured reproductive hormones and hormone-responsive tissues in infant boys. DESIGN The Infant Feeding and Early Development study was a prospective cohort of maternal-infant dyads requir...
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#1Mimi I. Hu (University of Texas MD Anderson Cancer Center)H-Index: 15
#2Steven G. Waguespack (University of Texas MD Anderson Cancer Center)H-Index: 39
Last. Richard T. KloosH-Index: 43
view all 16 authors...
CONTEXT Broad genomic analyses among thyroid histologies have been described from relatively small cohorts. OBJECTIVE Investigate the molecular findings across a large, real-world cohort of thyroid fine needle aspiration (FNA) samples. DESIGN Retrospective analysis of RNA sequencing data files. SETTING CLIA laboratory performing Afirma Genomic Sequencing Classifier (GSC) and Xpression Atlas (XA) testing. PARTICIPANTS 50,644 consecutive Bethesda III-VI nodules. INTERVENTION none. MAIN OUTCOME MEA...
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Top fields of study
Endocrinology
Insulin
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Thyroid
Diabetes mellitus
Hormone
Medicine
Biology