Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries
Abstract
The pathologic mechanisms of skin injuries, following the acute inflammatory response induced by vesicating agents sulfur mustard (SM) and nitrogen mustard (NM) exposure, are poorly understood. Neutrophils which accumulate at the site of injury, abundantly express myeloperoxidase (MPO), a heme protein that is implicated in oxidant-related antimicrobial and cytotoxic responses. Our previous studies have shown that exposure to SM analog...
Paper Details
Title
Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries
Published Date
Jun 1, 2014
Journal
Volume
320
Pages
25 - 33
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