Anil K. Jain
Banaras Hindu University
CancerInternal medicineEndocrinologyPathologyDNA damageChemistryApoptosisImmunologyIn vivoInflammationSilibininNitrogen mustardHairlessProstate cancerSulfur mustardTrampCancer researchMedicineBiologyPharmacology
52Publications
22H-index
863Citations
Publications 48
Newest
#1Parul Jain (P.G. College)
#2Anil K. Jain (BHU: Banaras Hindu University)H-Index: 22
Tax policy and tax administration are inextricably linked. The success of any tax policy depends to a large extent on efficient tax administration which would necessitate minimising arrears of asse...
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#1Gagan Deep (Wake Forest University)H-Index: 39
#2Anil K. Jain (UM: University of Montana)H-Index: 22
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 7 authors...
Approximately, 30 000 men die from prostate cancer (PCa) every year in the United States, mainly due to the metastasis. Thus, the key events associated with PCa metastasis are under rigorous investigation, with recent studies showing that preparation of pre-metastatic niches (PMN) in distant organs is an important step. However, the molecular basis for PMN preparation is still unclear. Hypoxia in primary tumors promotes aggressiveness; however, its precise role in metastasis is not clear. We rec...
12 CitationsSource
#1Cynthia M. Rigby (University of Colorado Denver)
#2Gagan DeepH-Index: 39
Last. Rajesh AgarwalH-Index: 104
view all 7 authors...
Non-melanoma skin cancers (NMSCs) account for about half of all malignancies diagnosed annually in the United States. Around 80% of NMSCs are basal cell carcinoma (BCC) and 20% are squamous cell carcinoma (SCC). Whereas the efficacy of several chemopreventive agents has been examined and reported against both BCC and SCC, a majority of these studies have focused on the test agent’s activity in a long-term setting to determine the amount of tumors formed. Notably, the studies evaluating the effic...
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#1Cindy Rigby (UM: University of Montana)H-Index: 1
#2Gagan Deep (UM: University of Montana)H-Index: 39
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 6 authors...
: Around 80% of nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC), still studies evaluating the efficacy of chemopreventive agents during early stage/s of BCC development are lacking. Accordingly, utilizing the well-established patched (Ptch)+/- mouse model of ultraviolet B (UVB) radiation-induced BCC formation, we excised skin samples from UVB exposed Ptch+/- and Ptch+/+ mice before tumor formation to study the promotion/progression of BCC and to determine the efficacy and target/...
3 CitationsSource
#1Komal Raina (University of Colorado Denver)H-Index: 30
#2Anil K. Jain (University of Colorado Denver)H-Index: 22
Last. Rajesh Agarwal (University of Colorado Denver)H-Index: 104
view all 6 authors...
Prostate cancer (PCa) is the most frequently diagnosed invasive malignancy and second leading cause of cancer-associated deaths in the males in the United States. Inositol hexaphosphate (IP6) a nutrient constituting 6.4% (w/w) or even higher levels in most cereals, legumes, nuts, oil seeds and soybean has been shown to protect against growth and progression of PCa in pre-clinical animal models. Our completed studies in a spontaneous transgenic mouse model of PCa (TRAMP) have shown that IP6 feedi...
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#1Gagan Deep (UM: University of Montana)H-Index: 39
#2Rahul Kumar (UM: University of Montana)H-Index: 7
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 8 authors...
Hypoxia is associated with aggressive phenotype and poor prognosis in prostate cancer (PCa) patients suggesting that PCa growth and progression could be controlled via targeting hypoxia-induced signaling and biological effects. Here, we analyzed silibinin (a natural flavonoid) efficacy to target cell growth, angiogenesis, and metabolic changes in human PCa, LNCaP, and 22Rv1 cells under hypoxic condition. Silibinin treatment inhibited the proliferation, clonogenicity, and endothelial cells tube f...
31 CitationsSource
#1Cynthia M. Rigby (UM: University of Montana)H-Index: 2
#2Srirupa Roy (UM: University of Montana)H-Index: 11
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 9 authors...
: Non-melanoma skin cancers (NMSC) are a growing problem given that solar ultraviolet B (UVB) radiation exposure is increasing most likely due to depletion of the atmospheric ozone layer and lack of adequate sun protection. Better preventive methods are urgently required to reduce UV-caused photodamage and NMSC incidence. Earlier, we have reported that silibinin treatment activates p53 and reduces photodamage and NMSC, both in vitro and in vivo; but whether silibinin exerts its protective effect...
20 CitationsSource
#1Harold Ting (UM: University of Montana)H-Index: 7
#2Gagan Deep (UM: University of Montana)H-Index: 39
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 6 authors...
Tumor microenvironment plays an essential role in prostate carcinogenesis and offers novel opportunities to prevent and treat prostate cancer (PCA). Here, we investigated the ability of cancer-associated fibroblasts (CAFs) to promote PCA progression, and silibinin efficacy to target this response. We collected conditioned media from CAFs treated with vehicle or silibinin, and labeled as control conditioned media (CCM) or silibinin-treatment conditioned media (SBCM), respectively. Next, we charac...
24 CitationsSource
#1Gagan Deep (UM: University of Montana)H-Index: 39
#2Rahul Kumar (UM: University of Montana)H-Index: 7
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 11 authors...
Prostate cancer (PCa) is the leading malignancy among men. Importantly, this disease is mostly diagnosed at early stages offering a unique chemoprevention opportunity. Therefore, there is an urgent need to identify and target signaling molecules with higher expression/activity in prostate tumors and play critical role in PCa growth and progression. Here we report that NADPH oxidase (NOX) expression is directly associated with PCa progression in TRAMP mice, suggesting NOX as a potential chemoprev...
27 CitationsSource
#1Chandagirikoppal V. Kavitha (UM: University of Montana)H-Index: 3
#2Anil K. Jain (UM: University of Montana)H-Index: 22
Last. Gagan Deep (UM: University of Montana)H-Index: 39
view all 10 authors...
Glioblastoma multiforme (GBM) is an untreatable malignancy. Existing therapeutic options are insufficient, and adversely affect functional and non-cancerous cells in the brain impairing different functions of the body. Therefore, there is an urgent need for additional preventive and therapeutic non-toxic drugs against GBM. Asiatic acid (AsA; 2,3,23-trihydroxy-12-ursen-28-oic acid, C30H48O5) is a natural small molecule widely used to treat various neurological disorders, and the present research ...
27 CitationsSource