Rajesh Agarwal
University of Montana
CancerInternal medicineEndocrinologyPathologyChemistryApoptosisImmunologyIn vivoDU145SilibininProstate cancerAngiogenesisCell cycleCancer researchBiochemistryCarcinogenesisCell growthMedicineBiologyCancer cellPharmacology
512Publications
108H-index
26.1kCitations
Publications 501
Newest
#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 9
#2Neha Mishra (Anschutz Medical Campus)
Last. Rajesh Agarwal (Anschutz Medical Campus)H-Index: 108
view all 9 authors...
Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917; corneas are particularly vulnerable to SM exposure. They may develop inflammation, ulceration, neovascularization (NV), impaired vision, and partial/complete blindness depending upon the concentration of SM, exposure duration, and bio-physiological conditions of the eyes. Comprehensive in vivo studies have established ocular structural alterations, opacity, NV, and inflammation upon short durations (<4 mi...
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#1Dominique Reed (UM: University of Montana)H-Index: 1
#2Dileep Kumar (UM: University of Montana)H-Index: 9
Last. Nichole Reisdorph (UM: University of Montana)H-Index: 31
view all 14 authors...
Abstract null null Background and aim null Metabolic syndrome (MetS) is a complex disease of physiological imbalances interrelated to abnormal metabolic conditions, such as abdominal obesity, type II diabetes, dyslipidemia and hypertension. In the present pilot study, we investigated the nutraceutical bitter melon (Momordica charantia L) -intake induced transcriptome and metabolome changes and the converging metabolic signaling networks underpinning its inhibitory effects against MetS-associated...
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Abstract null null Curcumin is a bioactive natural compound with a wide range of pharmacological properties, including antitumor activity; however, its clinical application has been limited because of its low solubility, stability, and bioavailability. In this study, a solid phase approach was proposed for the combinatorial synthesis of a mini library of the mimics of curcumin in good purity and yield. The non-effective findings in pancreatic cancer cells switched to strong growth inhibition and...
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#6Neera Tewari-Singh (MSU: Michigan State University)H-Index: 3
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#1Swati Sharma (MSU: Michigan State University)
#2Joshua A. Klein (MSU: Michigan State University)H-Index: 1
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 3
view all 9 authors...
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#1Neha Mishra (UM: University of Montana)
#2Komal Raina (UM: University of Montana)H-Index: 31
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 108
view all 3 authors...
Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq-Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongoing on SM-induced toxicity, delineating the precise molecular pathways is still an ongoing area of investigation; thus, it is important to attempt novel approaches to decipher these...
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#4Sangeeta Rao (CSU: Colorado State University)H-Index: 16
Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut microbiota. In this study, human stool microbiota from colorectal cancer (CRC) survivors that consumed rice bran daily was examined by fecal microbiota transplantation (FMT) for protection from azoxymeth...
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Lipid catabolism represents an Achilles heel in prostate cancer (PCa) that can be exploited for therapy. CPT1A regulates the entry of fatty acids into the mitochondria for beta-oxidation and its inhibition has been shown to decrease PCa growth. In this study, we examined the pharmacological blockade of lipid oxidation with ranolazine in TRAMPC1 PCa models. Oral administration of ranolazine (100 mg/Kg for 21 days) resulted in decreased tumor CD8+ T-cells Tim3 content, increased macrophages, and d...
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#1Deepanshi Dhar (UM: University of Montana)H-Index: 7
#2Komal Raina (UM: University of Montana)H-Index: 31
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 108
view all 10 authors...
Chemoresistance to gemcitabine (GEM)-a frontline chemotherapeutic, resulting from its dysfunctional uptake and metabolism in cancer cells, is a major contributing factor for failed therapy in pancreatic cancer (PanC) patients. Therefore, there is an urgent need for agents that could reverse GEM resistance and allow continued chemosensitivity to the drug. We employed natural nontoxic agent (with anti-PanC potential) bitter melon juice (BMJ) and GEM to examine their combinatorial benefits against ...
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