Neera Tewari-Singh
Michigan State University
SurgeryPathologyDNA damageChemistryApoptosisImmunologyOxidative stressLewisiteCorneaInflammationSilibininNitrogen mustardHairlessSulfur mustardEdemaToxicityPoison controlBiochemistryMedicineProtein kinase BBiologyCell biologyPharmacology
47Publications
17H-index
799Citations
Publications 37
Newest
#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
#2Rama Kant (Anschutz Medical Campus)H-Index: 8
Last. Rajesh Agarwal (Anschutz Medical Campus)H-Index: 104
view all 8 authors...
Abstract Sulfur mustard (SM), a potent vesicating chemical warfare agent, and its analog nitrogen mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory system are the main targets of SM and NM exposure; however, ocular tissue is most sensitive, resulting in severe ocular injury. The mechanism of ocular injury from vesicating agents' exposure is not completely understood. To understand the injury mechanism from exposure to vesicating agents, NM has been pr...
7 CitationsSource
#1Dinesh G Goswami (UM: University of Montana)H-Index: 8
#2Rajesh Agarwal (UM: University of Montana)H-Index: 104
Last. Neera Tewari-Singh (UM: University of Montana)H-Index: 17
view all 3 authors...
Abstract Phosgene Oxime (CX, Cl 2 CNOH), a halogenated oxime, is a potent chemical weapon that causes immediate acute injury and systemic effects. CX, grouped together with vesicating agents, is an urticant or nettle agent with highly volatile, reactive, corrosive, and irritating vapor, and has considerably different chemical properties and toxicity compared to other vesicants. CX is absorbed quickly through clothing with faster cutaneous penetration compared to other vesicating agents causing i...
5 CitationsSource
#1Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
#2Dinesh G Goswami (University of Colorado Denver)H-Index: 8
Last. Rajesh Agarwal (University of Colorado Denver)H-Index: 104
view all 6 authors...
#1Neera Tewari-SinghH-Index: 17
#2Dinesh G GoswamiH-Index: 8
Last. Rajesh AgarwalH-Index: 104
view all 10 authors...
: Lewisite (LEW), a potent arsenical vesicating chemical warfare agent, poses a continuous risk of accidental exposure in addition to its feared use as a terrorist weapon. Ocular tissue is exquisitely sensitive to LEW and exposure can cause devastating corneal lesions. However, detailed pathogenesis of corneal injury and related mechanisms from LEW exposure that could help identify targeted therapies are not available. Using an established consistent and efficient exposure system, we evaluated t...
6 CitationsSource
#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
#2Rama Kant (Anschutz Medical Campus)H-Index: 8
Last. Rajesh Agarwal (Anschutz Medical Campus)H-Index: 104
view all 4 authors...
Abstract Vesicating agent, Sulfur mustard (SM), causes devastating eye injury; however, there are no effective antidotes available. Using nitrogen mustard (NM), a bi-functional analog of SM, we have earlier reported that NM-induced corneal injury in ex vivo rabbit cornea organ culture model parallels corneal injury reported with SM. Using this model, we have demonstrated the therapeutic efficacy of dexamethasone (DEX), doxycycline (DOX) and silibinin (SB) in reversing NM (2 h exposure)-induced c...
7 CitationsSource
#1Dinesh G Goswami (University of Colorado Denver)H-Index: 8
#2Rama Kant (University of Colorado Denver)H-Index: 8
Last. Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
view all 9 authors...
#1Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
#2Dinesh G Goswami (University of Colorado Denver)H-Index: 8
Last. Rajesh Agarwal (University of Colorado Denver)H-Index: 104
view all 10 authors...
#1David A. Ammar (University of Colorado Denver)H-Index: 23
#2Dinesh G Goswami (University of Colorado Denver)H-Index: 8
Last. Neera Tewari-Singh (University of Colorado Denver)H-Index: 17
view all 8 authors...
#1Neera Tewari-Singh (UM: University of Montana)H-Index: 17
#2Dinesh G Goswami (UM: University of Montana)H-Index: 8
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 7 authors...
Abstract Phosgene Oxime (CX), an urticant or nettle agent categorized as a vesicant, is a potential chemical warfare and terrorist weapon. Its exposure can result in widespread and devastating effects including high mortality due to its fast penetration and ability to cause immediate severe cutaneous injury. It is one of the least studied chemical warfare agents with no effective therapy available. Thus, our goal was to examine the acute effects of CX following its cutaneous exposure in SKH-1 ha...
7 CitationsSource
#1Dinesh G Goswami (UM: University of Montana)H-Index: 8
#2Neera Tewari-Singh (UM: University of Montana)H-Index: 17
Last. Rajesh Agarwal (UM: University of Montana)H-Index: 104
view all 3 authors...
The vesicating agents sulfur mustard (SM) and lewisite (LEW) are potent chemical warfare agents that primarily cause damage to the ocular, skin, and respiratory systems. However, ocular tissue is the most sensitive organ, and vesicant exposure results in a biphasic injury response, including photophobia, corneal lesions, corneal edema, ulceration, and neovascularization, and may cause loss of vision. There are several reports on ocular injury from exposure to SM, which has been frequently used i...
17 CitationsSource