Toxicology
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#1Yuan Yuan (JLU: Jilin University)H-Index: 10
#2Ziyue Wang (JLU: Jilin University)H-Index: 1
Last. Haiyang Yan (JLU: Jilin University)H-Index: 1
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Abstract null null Furan is a genotoxic and carcinogenic toxicant formed during the food thermal processing. Our previous studies confirmed that salidroside (SAL) displayed excellent protective effects against furan-induced hepatotoxicity and inflammation, whereas the underlying mechanism was still unclear. In the current study, Balb/c mice were divided to the control group (CON), the furan model group (FUR8, 8 mg/kg BW furan for 30 days) and SAL intervention groups (SAL10/20/40, 8 mg/kg BW fura...
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#1Yangwei Li (SCAU: South China Agricultural University)
#2Yingwei Liu (SCAU: South China Agricultural University)
Last. Yung-Fu Chang (Cornell University)H-Index: 50
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Fluoride is one of the most widely distributed elements in nature, while some fluorine-containing compounds are toxic to several vertebrates at certain levels. The current study was performed to evaluate the nephrotoxic effects of fluoride exposure in ducks. The results showed that the renal index was decreased in NaF group, and fluoride exposure significantly decreased the levels of serum Albumin, Glucose, Total cholesterol, Urea, protein and Triglycerides, confirming that NaF exhibited adverse...
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#1Khaled A. Osman (Alexandria University)H-Index: 9
#2Eslam M. Ezz El-Din (Alexandria University)H-Index: 1
Last. Ayman El-Seedy (Alexandria University)H-Index: 5
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The attenuating effect of 150 mg/kg of N-acetylcysteine (NAC) against the oral administration of 7.88 and 202.07 mg/kg/day for 14 days of either chlropyrifos-ethyl (CPE-E) or chlropyrifos-methyl (CPF-M), respectively, in male rats was investigated using biochemical and genetic markers. Biomarkers such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), paraoxonase (PON), adenosine 5'-triphosphatase (ATP-ase), glutathione-S-transferase (GST), catalase (CAT), glutathione reduced (GSH) i...
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#1Alina EfremenkoH-Index: 7
Last. Harvey J. ClewellH-Index: 73
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Evidence from both in vivo and in vitro studies suggests that gene expression changes from long-term exposure to arsenite evolve markedly over time, including reversals in the direction of expression change in key regulatory genes. In this study, human uroepithelial cells from the ureter segments of 4 kidney-donors were continuously treated in culture with arsenite at concentrations of 0.1 or 1 µM for 60 days. Gene expression at 10, 20, 30, 40, and 60 days was determined using Affymetrix human g...
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#1Masashi Kawami (Hiroshima University)H-Index: 7
#2Shinnosuke Takenaka (Hiroshima University)H-Index: 1
Last. Mikihisa Takano (Hiroshima University)H-Index: 33
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Abstract null null Several studies using bleomycin (BLM)-induced lung injury rat model revealed that epithelial-mesenchymal transition (EMT) contributes to pulmonary fibrosis. Conversely, microRNAs (miRNAs) are considered as useful markers of various diseases. In the present study, we aimed to characterize the EMT state through focusing on alveolar epithelial cells and identify the miRNAs that can be used as markers to predict pulmonary fibrosis using a BLM-induced lung injury rat model. Intratr...
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#1Yujie Yao (NEAU: Northeast Agricultural University)H-Index: 1
#2Xia Zhao (NEAU: Northeast Agricultural University)H-Index: 10
Last. Shiwen Xu (NEAU: Northeast Agricultural University)H-Index: 52
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Abstract null null Cadmium (Cd) is a widely distributed environmental pollutant with immunotoxicity and endocrine toxicity. M1/M2 macrophages participate in the immune response and exert an essential influence on fibrosis. Nevertheless, whether Cd can induce porcineadrenal fibrosis by affecting the polarization of M1/M2 macrophages and its potential regulatory mechanism have not been explored. We added 20 mg/kg CdCl2 to the pig diet for 40 days to investigate the fibrogenic effect of subacute Cd...
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#1Merrie Mosedale (UNC: University of North Carolina at Chapel Hill)H-Index: 13
#2Yanwei Cai (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last. William Valdar (UNC: University of North Carolina at Chapel Hill)H-Index: 37
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Development of TAK-875 was discontinued when a small number of serious drug-induced liver injury (DILI) cases were observed in Phase 3 clinical trials. Subsequent studies have identified hepatocellular oxidative stress, mitochondrial dysfunction, altered bile acid homeostasis, and immune response as mechanisms of TAK-875 DILI and the contribution of genetic risk factors in oxidative response and mitochondrial pathways to the toxicity susceptibility observed in patients. We tested the hypothesis ...
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#1Ayan Mondal (USC: University of South Carolina)H-Index: 6
#2Punnag Saha (USC: University of South Carolina)H-Index: 4
Last. Mitzi Nagarkatti (USC: University of South Carolina)H-Index: 66
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Abstract null null Nonalcoholic fatty liver disease (NAFLD) has been shown to be associated with extrahepatic comorbidities including neuronal inflammation and Alzheimer’s-like pathology. Environmental and genetic factors also act as a second hit to modulate severity and are expected to enhance the NAFLD-linked neuropathology. We hypothezied that environmental microcystin-LR (MC-LR), a toxin produced by harmful algal blooms of cyanobacteria, exacerbates the neuroinflammation and degeneration of ...
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#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Kate Hoffman (Duke University)H-Index: 29
Last. Astrid Saraceni (UNITO: University of Turin)
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The 3T3-L1 murine pre-adipocyte line is an established cell culture model for screening Metabolism Disrupting Chemicals (MDCs). Despite a need to accurately identify MDCs for further evaluation, relatively little research has been performed to comprehensively evaluate reproducibility across laboratories, assess factors that might contribute to varying degrees of differentiation between laboratories (media additives, plastics, cell source, etc.), or to standardize protocols. As such, the goals of...
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#1Hao Li (Western University of Health Sciences)H-Index: 1
#2Qingshun Quinn Li (Western University of Health Sciences)H-Index: 27
Last. Yiling Hong (Western University of Health Sciences)H-Index: 6
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Silver nanoparticles (AgNPs) are widely used in medical and commercial products for their unique antibacterial functions. However, the impact of AgNPs on human neural development is not well understood. To investigate the effect of AgNPs on human neural development, various doses of 20 nm citrate-coated AgNP (AgSC) were administered to human embryonic stem cell derived neural progenitors during the neuronal differentiation. Immunofluorescence staining with neuronal progenitor markers SOX2 (sex d...
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