Original paper
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Abstract
Diabetic foot ulceration is a major complication of diabetes. Substance P (SP) is involved in wound healing, but its effect in diabetic skin wounds is unclear. We examined the effect of exogenous SP delivery on diabetic mouse and rabbit wounds. We also studied the impact of deficiency in SP or its receptor, neurokinin-1 receptor, on wound healing in mouse models. SP treatment improved wound healing in mice and rabbits, whereas the absence of SP...
Paper Details
Title
Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype
Published Date
Jun 1, 2015
Volume
185
Issue
6
Pages
1638 - 1648
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