Eugénia Carvalho
University of Arkansas for Medical Sciences
Insulin receptorEndocrinologyGlucose transporterAdipose tissueChemistryImmunologyGLUT4InflammationInsulin resistanceDiabetic footGlucose uptakeInsulinWound healingAngiogenesisCyclosporin aDiabetes mellitusMedicineProtein kinase BBiologyPharmacology
Publications 101
#1Jin-Ran Chen (University of Arkansas for Medical Sciences)H-Index: 26
#2Oxana P. Lazarenko (University of Arkansas for Medical Sciences)H-Index: 19
Last. Elisabet BørsheimH-Index: 27
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#1Jin-Ran ChenH-Index: 1
#2Oxana P. LazarenkoH-Index: 19
Last. Elisabet BørsheimH-Index: 27
view all 7 authors...
#1Michelle Vang Mouritzen (RU: Roskilde University)H-Index: 4
#2M. Petkovic (UC: University of Coimbra)H-Index: 1
Last. Håvard Jenssen (RU: Roskilde University)H-Index: 38
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Abstract Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties, however, the effects on diabetic wound healing remain poorly understood. The wound healing potential of LFcinB was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears. A type 1 diabetic mouse model was also used to evaluate wound healing kinetics, bacterial diversity patterns and the effect of LFcinB on oxidative stress,...
#1Hélia Fernandes (UC: University of Coimbra)
#2João Elói Moura (UC: University of Coimbra)H-Index: 8
Last. Eugénia Carvalho (UC: University of Coimbra)H-Index: 33
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Blood is generated throughout life by continued proliferation and differentiation of hematopoietic progenitors, while at the top of the hierarchy, hematopoietic stem cells (HSCs) remain largely quiescent. This way HSCs avoid senescence and preserve their capacity to repopulate the hematopoietic system. But HSCs are not always quiescent, proliferating extensively in conditions such as those found in the fetal liver. Understanding the elusive mechanisms that regulate HSC fate would enable us to co...
#1Chhanda Bose (TTU: Texas Tech University)H-Index: 1
#2Inês N Alves (UC: University of Coimbra)H-Index: 2
Last. Sharda P Singh (TTU: Texas Tech University)H-Index: 1
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Age-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. Sulforaphane (SFN), a natural compound Nrf2-related activator of cytoprotective genes, provides protection in several disease states includin...
3 CitationsSource
#1M. Petkovic (UC: University of Coimbra)H-Index: 1
Last. Louise Torp DalgaardH-Index: 25
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Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNA...
1 CitationsSource
#1Se-Ran Jun (University of Arkansas for Medical Sciences)H-Index: 16
#2Amrita K. CheemaH-Index: 28
Last. Sharda P. Singh (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 21
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Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6-8 weeks) and old (21-22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled t...
#1Ana Elizabeth Figueiredo (UC: University of Coimbra)H-Index: 17
#1Ana Figueiredo (UC: University of Coimbra)H-Index: 3
Last. Eugénia Carvalho (UC: University of Coimbra)H-Index: 33
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Abstract Non-healing diabetic foot ulcers (DFUs) are a serious complication in diabetic patients. Their incidence has increased in recent years. Although there are several treatments for DFUs, they are often not effective enough to avoid amputation. Protein tyrosine phosphatase 1B (PTP1B) is expressed in most tissues and is a negative regulator of important metabolic pathways. PTP1B is overexpressed in tissues under diabetic conditions. Recently, PTP1B inhibition has been found to enhance wound ...
4 CitationsSource
#1Patricia Monteiro Seraphim (UNESP: Sao Paulo State University)H-Index: 12
#2Ermelindo C. Leal (UC: University of Coimbra)H-Index: 22
Last. Eugénia CarvalhoH-Index: 33
view all 6 authors...
Abstract AIMS: This study aimed to investigate the effect of lymphocytes in wound healing and the underlying mechanisms, in diabetic and non-diabetic mice, using Balb/c recombination activating gene (Rag)-2 and interleukin 2 receptor gamma (IL-2Rγ) double knockout (KO) (RAG2−/− IL-2Rγ−/−) mice. MAIN METHODS: Wound healing in vivo was performed in control and STZ-induced diabetic mice, in both KO and WT mice. Inflammation and ROS production were evaluated by immunofluorescence microscopy analysis...
2 CitationsSource
#1Ana FigueiredoH-Index: 3
Last. Eugénia CarvalhoH-Index: 33
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Peripheral neuropathy plays a role in chronic diabetic foot ulcers (DFUs), also leading to an imbalance in inflammation, as pro-inflammatory macrophages (M1) have difficulty switching to an anti-inflammatory phenotype (M2) contributing to a chronic inflammatory phase and healing impairment. Protein tyrosine phosphatase 1B (PTP1B), in the skin, is over expressed in diabetes and DFUs. We aimed to evaluate the role of PTP1B inhibition in macrophage under high glucose conditions. THP-1 monocytic cel...