Aristidis Veves
Beth Israel Deaconess Medical Center
VasodilationMicrocirculationEndocrinologySurgeryFoot (unit)CardiologyInflammationEndotheliumType 2 diabetesBrachial arteryDiabetic footDiabetic foot ulcerDiabetic neuropathyPeripheral neuropathyWound healingEndothelial dysfunctionVibration perceptionDiabetes mellitusMedicineComplication
234Publications
60H-index
13.9kCitations
Publications 210
Newest
#1Huan Yang (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 35
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Janet Mullington (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 35
view all 8 authors...
Source
#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)
#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)H-Index: 9
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 136
view all 3 authors...
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.
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#1G. Theocharidis (Emory University)
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Manoj BhasinH-Index: 41
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To understand the diabetic wound healing microenvironment, we profiled 174,962 single cells from foot, forearm, and PBMCs using single-cell RNA sequencing (scRNASeq) approach. Our analysis shows enrichment of a unique population of fibroblasts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1, and TNFAIP6 genes and M1 macrophage polarization in the DFU patients with healing wounds. Further, scRNASeq of spatially separated samples from same patient and spatial transcriptomics (ST) revealed preferen...
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#1Avi Smith (Tufts University)H-Index: 10
#2Trishawna Watkins (Tufts University)
Last. Jonathan A. Garlick (Tufts University)H-Index: 32
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1 CitationsSource
Source
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 60
view all 16 authors...
Non-healing diabetic foot ulceration (DFU) is characterized by low grade chronic inflammation, both locally and systemically. We prospectively followed a group of DFU patients who either healed or developed non-healing chronic DFU. Serum and forearm skin analysis, both at protein expression and transcriptomic level, indicated that increased expression of factors such as IFNγ, VEGF and sVCAM-1 were associated with DFU healing. Furthermore, foot skin single-cell RNA-seq analysis showed multiple fi...
5 CitationsSource
#1Jie Dong (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
#2Lihong Chen (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 60
view all 7 authors...
Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in connective tissues. Apart from their classical role in allergies, MCs also mediate various inflammatory responses due to the nature of their secretory products. They are involved in important physiological and pathophysiological responses related to inflammation, chronic wounds, and autoimmune diseases. There are also indications that MCs are associated with diabetes and its complications. MCs and MC-derived...
1 CitationsSource
#1Jessie P. Bakker (Harvard University)H-Index: 21
#2Dimitrios BaltzisH-Index: 5
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 60
view all 11 authors...
Rationale: Although both type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently recognized as risk factors for cardiovascular disease, little is known about their inter...
5 CitationsSource
#1Ana Tellechea (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 12
#2Sha Bai (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 60
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ABSTRACT Impaired wound healing in the diabetic foot is a major problem often leading to amputation. Mast cells have been shown to regulate wound healing in diabetes. We developed an indole-carboxamide type mast cell stabilizer, MCS-01, which proved to be an effective mast cell degranulation inhibitor in vitro and can be delivered topically for prolonged periods through controlled release by specifically designed alginate bandages. In diabetic mice, both pre- and post-wounding, topical MCS-01 ap...
13 CitationsSource
#1Triantafyllos Didangelos (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 10
#2Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 60
: Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people with diabetes mellitus, and are major risk factors for foot ulceration, amputation and cardiovascular dysfunction. Peripheral neuropathies manifest with either painful or painless symptoms, but many patients experience both. Once diagnosed appropriately, painful diabetic neuropathy management presents a unique challenge for physicians and should be considered as a syndrome, clinically distinct from dia...
3 CitationsSource