Aristidis Veves
Beth Israel Deaconess Medical Center
VasodilationInternal medicineMicrocirculationEndocrinologySurgeryPathologyFoot (unit)CardiologyInflammationEndotheliumType 2 diabetesBrachial arteryDiabetic footDiabetic neuropathyPeripheral neuropathyWound healingEndothelial dysfunctionVibration perceptionDiabetes mellitusMedicineComplication
238Publications
76H-index
14.5kCitations
Publications 239
Newest
#1Christopher H. Gibbons (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 35
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
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Background and aims null Neuropathy is a major cause of morbidity and mortality in individuals with diabetes, with no effective therapy to alter the inevitable progression of nerve damage. We hypothesized that mesenchymal stroma cell-like populations, that are characterized as immune modulators also have the potential of inducing angiogenesis and neurite outgrowth, might be useful in treating diabetic peripheral neuropathy (DPN). The aims of this study were to investigate the efficacy and safety...
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#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Hyunwoo Yuk (MIT: Massachusetts Institute of Technology)H-Index: 22
Last. Navin Jayaswal (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
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Chronic wounds with impaired healing capability such as diabetic foot ulcers (DFU) are devastating complications in diabetic patients, inflicting rapidly growing clinical and economic burdens in aging societies. Despite recent advances in therapeutic approaches, limited benefits of the existing solutions highlight the critical need for novel therapeutic solutions for diabetic wound healing. Here we propose a strain-programmable patch capable of rapid robust adhesion on and programmable mechanica...
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#1Huan Yang (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 42
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Janet Mullington (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 37
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Epidemiological studies have reported strong association between sleep loss and hypertension with unknown mechanisms. This study investigated macrovascular and microcirculation changes and inflammatory markers during repetitive sleep restriction. Sex differences were also explored. Forty-five participants completed a 22-day in-hospital protocol. Participants were assigned to, (1) eight-hour sleep per night (control), or (2) sleep restriction (SR) condition: participants slept from 0300 to 0700 h...
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#1Francesca M Chappell (Edin.: University of Edinburgh)H-Index: 30
#2Fay CrawfordH-Index: 20
Last. Richard D Riley (Keele University)H-Index: 70
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Introduction The aim of the study was to develop and validate a clinical prediction rule (CPR) for foot ulceration in people with diabetes. Research design and methods Development of a CPR using individual participant data from four international cohort studies identified by systematic review, with validation in a fifth study. Development cohorts were from primary and secondary care foot clinics in Europe and the USA (n=8255, adults over 18 years old, with diabetes, ulcer free at recruitment). U...
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#1Sarah Kelangi (Harvard University)H-Index: 1
#2Georgios Theocharidis (Harvard University)
Last. Marianna Bei (Harvard University)H-Index: 18
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#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)
#1Simon Matoori (Wyss Institute for Biologically Inspired Engineering)H-Index: 9
Last. David J. Mooney (Wyss Institute for Biologically Inspired Engineering)H-Index: 165
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Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.
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#1G. Theocharidis (Emory University)
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Manoj BhasinH-Index: 49
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To understand the diabetic wound healing microenvironment, we profiled 174,962 single cells from foot, forearm, and PBMCs using single-cell RNA sequencing (scRNASeq) approach. Our analysis shows enrichment of a unique population of fibroblasts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1, and TNFAIP6 genes and M1 macrophage polarization in the DFU patients with healing wounds. Further, scRNASeq of spatially separated samples from same patient and spatial transcriptomics (ST) revealed preferen...
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#1Avi Smith (Tufts University)H-Index: 10
#2Trishawna Watkins (Tufts University)H-Index: 1
Last. Jonathan A. Garlick (Tufts University)H-Index: 34
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A major challenge in the management of patients suffering from diabetes is the risk of developing nonhealing foot ulcers. Most in vitro methods to screen drugs for wound healing therapies rely on conventional 2D cell cultures that do not closely mimic the complexity of the diabetic wound environment. In addition, while three-dimensional (3D) skin tissue models of human skin exist, they have not previously been adapted to incorporate patient-derived macrophages to model inflammation from these wo...
1 CitationsSource
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#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
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Non-healing diabetic foot ulceration (DFU) is characterized by low grade chronic inflammation, both locally and systemically. We prospectively followed a group of DFU patients who either healed or developed non-healing chronic DFU. Serum and forearm skin analysis, both at protein expression and transcriptomic level, indicated that increased expression of factors such as IFNγ, VEGF and sVCAM-1 were associated with DFU healing. Furthermore, foot skin single-cell RNA-seq analysis showed multiple fi...
5 CitationsSource