Effectiveness and safety of immune checkpoint inhibitors in combination with palliative radiotherapy in advanced melanoma: A systematic review

Radiotherapy is frequently added to immune checkpoint inhibitors (ICI) when treating melanoma. We sought to describe the efficacy of combination ICI and palliative radiotherapy (pRT) and assess safety, focusing on immune related adverse events (irAE).A systematic search for studies investigating the combination of pRT and ICI was conducted.Five hundred-two articles were identified; nine met inclusion criteria. Improvements in objective response...