Critical Reviews in Oncology Hematology
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#1Antonio Russo (University of Palermo)H-Index: 102
#2Lorena Incorvaia (University of Palermo)H-Index: 17
Last. Ada Maria Florena (University of Palermo)H-Index: 27
view all 21 authors...
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic thera...
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Stereotactic radiosurgery (SRS) in combination with immunotherapy (IT) is increasingly used in the setting of melanoma and non-small cell lung cancer (NSCLC) brain metastases (BM). The synergistic properties of this treatment combination are still not deeply understood. IT-SRS appropriate combination has been envisioned as a strategic point in patients' management. Authors performed a systematic review on current evidences up to December 2020. The impact of SRS-IT and different IT schedules on s...
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Abstract null null Malignant tumors in young patients present a significant therapeutic challenge for physicians, partially due to their rarity and a relative lack of data, at least compared to adult tumors. As a result, there is an urgent need to explore new possible therapeutic regimens, either by introducing novel agents or by exploring combinations of existing agents. Vincristine, Temozolomide and Irinotecan are chemotherapeutic drugs which have emerged over the last six decades as monothera...
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#1Arsenije Kojadinovic (ISMMS: Icahn School of Medicine at Mount Sinai)
#2Bahar Laderian (Cleveland Clinic)
Last. Prabhjot Mundi (Veterans Health Administration)
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Abstract null null The NTRK genes encode the tropomyosin-related receptor tyrosine kinases TrkA, TrkB and TrkC. TRK receptors regulate the proliferation, differentiation, and survival of many neuronal and non-neuronal glial cells during embryogenesis, thus playing a critical role in synaptic plasticity and the development of nociceptive pathways. Recurrent genomic alterations in NTRK genes, typically fusions involving the 3′ region encoding the kinase domain juxtaposed to 5′ sequences from numer...
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#1Giovanni Maria Iannantuono (University of Rome Tor Vergata)
#2Lidia StrigariH-Index: 32
Last. Francesco Torino (University of Rome Tor Vergata)H-Index: 22
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The "burned out" or "burnt out" testicular cancer (BTC) indicates the spontaneous and complete regression of a testicular germ cell tumor in the presence of distant metastases at the diagnosis. As this condition was never reviewed systematically, a scoping review was conducted to scrutinize the available literature on clinical and histological features of BTC patients. Medline was searched from inception to 19 April 2020. A virtual cohort of 68 BTC patients was generated. Our findings highlighte...
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#1Giulio Francolini (UniFI: University of Florence)H-Index: 13
#2Beatrice Detti (UniFI: University of Florence)H-Index: 20
Last. Daniele ScartoniH-Index: 7
view all 16 authors...
Abstract null null Background null Moderately hypofractionated radiotherapy (RT) currently represents the standard RT approach for all prostate cancer (PCa) risk categories. We performed a systematic review and meta-analysis of available literature, focusing on acute and late genitourinary (GU) and gastrointestinal (GI) adverse events (AEs) of moderate hypofractionation for localized PCa. null null null Materials and methods null Literature search was performed and two independent reviewers sele...
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#1Sarah Weller (Twitter)
#2Nicolas H. Hart (University of Notre Dame Australia)H-Index: 15
Last. Morten Quist (Twitter)
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Abstract null null Background null Exercise has the potential to improve physical function and quality of life in individuals with bone metastases but is often avoided due to safety concerns. This systematic review summarizes the safety, feasibility and efficacy of exercise in controlled trials that include individuals with bone metastases. null null null Methods null MEDLINE, Embase, Pubmed, CINAHL, PEDro and CENTRAL databases were searched up to July 16, 2020. null null null Results null A tot...
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#1Michela Buglione (University of Brescia)H-Index: 21
#2Andrea Emanuele Guerini (University of Brescia)H-Index: 3
Last. A. AlghisiH-Index: 1
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Abstract null null Background null Secondary malignant neoplasms (SMNs) and cardiovascular diseases induced by chemotherapy and radiotherapy represent the main cause of excess mortality for early-stage Hodgkin lymphoma patients, especially when the mediastinum is involved. Conformal radiotherapy techniques such as Intensity-Modulated Radiation Therapy (IMRT) could allow a reduction of the dose to the organs-at-risk (OARs) and therefore limit long-term toxicity. null null null Methods null We per...
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#1M.C. Sanmartin (Instituto de Biología y Medicina Experimental)
#2Francisco Raúl Borzone (Instituto de Biología y Medicina Experimental)H-Index: 3
Last. Norma Alejandra Chasseing (Instituto de Biología y Medicina Experimental)H-Index: 9
view all 6 authors...
Abstract null null Breast cancer is one of the most common oncological pathologies in women worldwide. While its early diagnosis has considerably improved, about 70 % of advanced patients develop bone metastases with a high mortality rate. Several authors demonstrated that primary breast cancer cells prepare their future metastatic niche –known as the pre-metastatic niche- to turn it into an “optimal soil” for colonization. The role of the different cellular components of the bone marrow/bone ni...
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#1Mikaela Dell’Oro (UniSA: University of South Australia)H-Index: 3
#2Michala Short (UniSA: University of South Australia)H-Index: 6
Last. Eva Bezak (University of Adelaide)H-Index: 21
view all 4 authors...
Abstract null null Background null Proton radiotherapy (PT) is used increasingly for paediatric brain cancer patients. However, as demonstrated here, the knowledge on normal tissue dose constraints, to minimize side-effects, for this cohort is limited. null null null Methods null A search strategy was systematically conducted on MEDLINE® database. 65 papers were evaluated ranging from 2013-2021. null null null Results null Large variations in normal tissue tolerance and toxicity reporting across...
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