Transcriptomic drug-response gene signatures are informative for the stratification of patients for clinical trials

Asthma is a chronic heterogeneous inflammatory disorder of the airways with mixed lymphocytic and myelogenous infiltrates. Cellular characterization of this disorder has identified 4 phenotypes: eosinophilic (T2), neutrophilic (T1), mixed eosinophilic/neutrophilic, and paucigranulocytic.1Simpson J.L. Scott R. Boyle M.J. Gibson P.G. Inflammatory subtypes in asthma: assessment and identification using induced sputum.Respirology. 2006; 11:...