The Journal of Allergy and Clinical Immunology
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#1Emma Guttman-Yassky (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 70
#2Ana B. Pavel (University of Mississippi)H-Index: 23
Last. Elena Peeva (Pfizer)H-Index: 9
view all 16 authors...
Abstract null Background null Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. null Objective null To conduct a biopsy sub-study during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the efficacy and safety of ritlecitinib, an inhibitor of JAK3 and the tyrosine kinase expressed in hepatocellular carcin...
#1Vandamme Céline (UEF: University of Eastern Finland)
#2Rytkönen-Nissinen Marja (UEF: University of Eastern Finland)
Last. Virtanen Tuomas (UEF: University of Eastern Finland)
view all 7 authors...
ABSTRACT null Background null Allergen-specific type 2 CD4+ T helper (Th2) cells are critically involved in the pathogenesis of IgE-mediated allergic diseases. However, the heterogeneity of the Th2 response has only recently been appreciated. null Objective null To characterize at the single-cell level the ex vivo phenotype, transcriptomic profile and TCR repertoire of circulating CD4+ T cells specific to the major dog allergens Can f 1, Can f 4 and Can f 5 in subjects with and without dog aller...
#1Tsuguhisa Nakayama (Jikei University School of Medicine)H-Index: 6
#2Ivan T. Lee (SU: Stanford University)H-Index: 8
Last. Jayakar V. Nayak (VHA: Veterans Health Administration)H-Index: 26
view all 20 authors...
Abstract null Background null Emerging evidence suggests that chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease with disparate inflammatory characteristics between different racial groups and geographies. Little is known currently about possible distinguishing factors underlying these inflammatory differences. null Objective null To interrogate for differences between Caucasian and Japanese CRSwNP disease using whole transcriptome and single-cell RNA gene expres...
#1Ahmed O ShalashH-Index: 3
#2Waleed M. HusseinH-Index: 20
Last. Istvan TothH-Index: 47
view all 4 authors...
Hookworms are hematophagous nematode parasites that have infected a billion people worldwide. Anthelmintic drugs have limited efficacy and do not prevent reinfection. Therefore, prophylactic vaccines are in high demand. Whole parasite vaccines are allergic and unsafe; thus, research into subunit vaccines has been warranted. A comprehensive overview of protein or peptide subunit vaccines’ safety, protective efficacy, and associated immune responses is provided herein. The differences between the ...
#1Lam C. Tsoi (UM: University of Michigan–Ann Arbor)H-Index: 30
Last. Johann E. Gudjonsson (UM: University of Michigan–Ann Arbor)H-Index: 37
view all 16 authors...
Background null Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic, chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The pathogenesis of PN is not well understood but is believed to involve cross talk between sensory nerve fibers, immune cells, and the epidermis. It is centered around the neuroimmune cytokine IL-31, driving an intractable itch–scratch cycle. null Objective null We sought to provide a comprehensive view of the transcrip...
#1Katherine A. OwenH-Index: 13
#2Amrie C. GrammerH-Index: 29
Last. Peter E. LipskyH-Index: 91
view all 3 authors...
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of non–European ancestry experience the disease more severely, exhibiting an increased incidence of cardiovascular disease, renal involvement, and tissue damage compared with European ancestry populations. Furthermore, there seems to be variability in the response of individuals within different ancestral groups to standard medications, including cyclopho...
#1Steve N. Georas (URMC: University of Rochester Medical Center)H-Index: 39
#2Rosalind J. Wright (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 53
Last. Patricia Noel (NIH: National Institutes of Health)H-Index: 7
view all 60 authors...
Abstract null Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has re...
#1Haerin Jang (Yonsei University)H-Index: 3
#2Eun Gyul Kim (Yonsei University)H-Index: 2
Last. Kyung Won Kim (Yonsei University)H-Index: 28
view all 7 authors...
ABSTRACT null null Background null The pathophysiology of childhood food allergy (FA) and its natural history are poorly understood. Clarification of the underlying mechanism may aid in identifying novel biomarkers and strategies for clinical intervention in children with FA. null null null Objective null This study aimed to identify metabolites associated with the development and resolution of FA. null null null Methods null The metabolomic profiles of 20 children with FA and 20 healthy control...
#1Julia L M Dunn (CCHMC: Cincinnati Children's Hospital Medical Center)H-Index: 1
#2Marc E. Rothenberg (CCHMC: Cincinnati Children's Hospital Medical Center)H-Index: 96
This review highlights recent advances in the understanding of eosinophils and eosinophilic diseases, particularly eosinophilic gastrointestinal diseases during the last year. The increasing incidence of diseases marked by eosinophilia has been documented and highlighted the need to understand eosinophil biology and eosinophilic contributions to disease. Significant insight into the nature of eosinophilic diseases has been achieved using next-generation sequencing technologies, proteomic analysi...
#1Shuai Shao (UM: University of Michigan–Ann Arbor)H-Index: 14
#2Allison C. Billi (UM: University of Michigan–Ann Arbor)H-Index: 13
Last. Johann E. Gudjonsson (UM: University of Michigan–Ann Arbor)H-Index: 37
view all 3 authors...
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