The Journal of Allergy and Clinical Immunology
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#1Matthew C. Altman (UW: University of Washington)H-Index: 11
#2Kaitlin J. Flynn (BRI: Benaroya Research Institute)H-Index: 5
Last. Daniel J. Jackson (UW: University of Wisconsin-Madison)H-Index: 34
view all 25 authors...
Abstract Background Mucus plugging can worsen asthma control, lead to reduced lung function and fatal exacerbations. MUC5AC is the secretory mucin implicated in mucus plugging, and MUC5AC gene expression has been associated with development of airway obstruction and asthma exacerbations in urban children with asthma. However, the genetic determinants of MUC5AC expression are not established. Objective To assess single-nucleotide polymorphisms (SNPs) that influence MUC5AC expression and relate to...
#1Robert Ose (University of Mainz)H-Index: 1
#2Benno Weigmann (FAU: University of Erlangen-Nuremberg)H-Index: 29
Last. Iris Bellinghausen (University of Mainz)H-Index: 21
view all 6 authors...
Abstract Background CD56-expressing natural killer (NK) cells as well as invariant natural killer T (iNKT) cells have been shown to either promote or inhibit allergic immune responses. Objective The aim of the present study was to investigate the impact of these cells in a recently developed humanized mouse model of allergen-induced IgE-dependent gut and lung inflammation. Methods Nonobese diabetic-severe combined immunodeficiency-γc-/- mice were injected intraperitoneally with human PBMC or CD5...
#1Hyuk Jee (Boston Children's Hospital)
#2Z. Huang (Brigham and Women's Hospital)H-Index: 2
Last. Pui Y. Lee (Brigham and Women's Hospital)H-Index: 26
view all 17 authors...
BACKGROUND Deficiency of adenosine deaminase 2 (DADA2) is an autoinflammatory disease caused by deleterious ADA2 variants. The frequency of these variants in the general population, and hence the expected disease prevalence, remain unknown. OBJECTIVE We aim to characterize the functional impact and carrier frequency of ADA2 variants. METHODS We performed functional studies and in silico analysis on 163 ADA2 variants, including DADA2-associated variants and population variants identified in the G...
#1Alexandre Le Joncour (University of Paris)H-Index: 1
#2A.C. Desbois (University of Paris)H-Index: 5
Last. David Saadoun (University of Paris)H-Index: 58
view all 21 authors...
ABSTRACT : Background Takayasu arteritis (TAK) is a large vessel vasculitis (LVV) resulting in artery wall remodeling with segmental stenosis and/or aneurysm formation. Mast cells (MC) are instrumental in bridging cell injury and inflammatory response. Objective To investigate the contribution of MC on vessel permeability, angiogenesis and fibrosis in TAK patients. Methods MC activation and their tissue expression were assessed in sera and in aorta from patients with Takayasu arteritis (TAK) and...
#1Matthias Haimel (Austrian Academy of Sciences)H-Index: 16
#2Julia Pazmandi (Austrian Academy of Sciences)H-Index: 2
Last. Kaan BoztugH-Index: 34
view all 38 authors...
Abstract BACKGROUND Accurate, detailed and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date the use of HPO has not yet been widely implemented in the field of inborn errors of immunity (IEIs), mainly due...
#1Luke F. Pennington (Stanford University)H-Index: 6
#2Pascal Gasser (University of Bern)H-Index: 4
Last. Theodore S. Jardetzky (Stanford University)H-Index: 53
view all 6 authors...
Abstract: Background Anaphylaxis represents one of the most severe and fatal forms of allergic reactions. Like most other allergies, it is caused upon activation of basophils and mast cells by allergen-mediated cross-linking of immunoglobulin E (IgE) bound to its high affinity receptor FceRI on the cell surface. The systemic release of soluble mediators induces an inflammatory cascade rapidly causing symptoms with peak severity in minutes to hours after allergen exposure. Primary treatment for a...
#1Alexander Troelnikov (South Australia Pathology)
#2Griffith B. Perkins (University of Adelaide)H-Index: 1
Last. Pravin Hissaria (Royal Adelaide Hospital)H-Index: 11
view all 7 authors...
Abstract Background The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene glycol (PEG) contained in the lipid nanoparticle suspected as being the cause. Objective To evaluate the performance of skin testing and basophil activation testing to PEG, polysorbate 80, BNT162b2 and AZD1222 (Astra-Zeneca) COVID-19 vaccines in patients with a history of PEG allergy. Methods Three known PEG allergic participants and three healthy control...
#1Justin A. Jarrell (Stanford University)H-Index: 11
#1Justin A. Jarrell (VA Palo Alto Healthcare System)
Last. William H. Robinson (Stanford University)H-Index: 65
view all 14 authors...
Abstract Background IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition involving loss of B cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined. Objective To identify novel autoantibodies and autoantigen targets that promote pathogenic responses in IgG4-RD. Methods We sequenced plasmablast antibody repertoires in patients with IgG4-RD. Representative monoclonal antibodies (mAb) were expres...
#1Luís Almeida (MHH: Hannover Medical School)H-Index: 3
#2Ayesha Dhillon-LaBrooy (MHH: Hannover Medical School)H-Index: 2
Last. Tim Sparwasser (University of Mainz)H-Index: 63
view all 5 authors...
The progression through different steps of T-cell development, activation, and effector function is tightly bound to specific cellular metabolic processes. Previous studies established that T-effector cells have a metabolic bias toward aerobic glycolysis, whereas naive and regulatory T cells mainly rely on oxidative phosphorylation. More recently, the field of immunometabolism has drifted away from the notion that mitochondrial metabolism holds little importance in T-cell activation and function...
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