The Journal of Allergy and Clinical Immunology
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#1Eeva Sliz (University of Oulu)H-Index: 5
#2Laura Huilaja (University of Oulu)H-Index: 14
Last. Sirkku Peltonen (Sahlgrenska University Hospital)
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BACKGROUND Atopic dermatitis (AD) is a common chronic inflammatory skin disease with high heritability. Previous genome-wide association studies have identified several loci predisposing to AD. These findings explain approximately 30% of the variance in AD susceptibility, suggesting that further work is required to fully understand the genetic underpinnings. OBJECTIVE We sought to gain additional understanding of the genetic contribution to AD risk by using biobank resources. METHODS We complete...
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#1George E Fragoulis (Glas.: University of Glasgow)H-Index: 16
#2James Brock (Glas.: University of Glasgow)
Last. Stefan Siebert (Glas.: University of Glasgow)H-Index: 25
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Abstract null null JAK inhibitors (JAKi) are a new class of targeted therapy that have entered clinical practice for the treatment of immune-mediated rheumatic conditions. JAKi can block the signalling activity of a variety of pro-inflammatory cytokines and therefore have the potential to mediate therapeutic benefits across a wide range of immune-mediated conditions. Several JAKi are licensed and many more undergoing clinical trials. Here we provide a narrative review of the current and upcoming...
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#1Kaoruko Shimizu (Hokkaido University)H-Index: 12
#2Naoya Tanabe (Kyoto University)H-Index: 17
Last. Masaharu Nishimura (Hokkaido University)H-Index: 77
view all 11 authors...
Abstract null Background null Fixed airflow obstruction (FAO) in asthma, particularly in non-smoking subjects, is generally believed to be caused by airway remodeling. However, parenchymal destruction may also contribute to FAO and longitudinal decline in forced expiratory volume in 1 sec (FEV1). null Objectives null To evaluate parenchymal destruction using emphysema indices, exponent D and low attenuation area percent (LAA%) on computed tomography (CT), and test whether the parenchymal destruc...
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#1Raj Chovatiya (NU: Northwestern University)H-Index: 2
#2Amy S. Paller (NU: Northwestern University)H-Index: 36
Atopic dermatitis is a chronic inflammatory skin disorder associated with heterogenous presentation and often immense patient burden. Safe, targeted treatment options are currently limited. We conducted a focused review of the published literature, including clinical trial results, case reports, and abstracts, as well as presentations from scientific meetings and data from industry press releases, to describe the use of topical and systemic janus kinase (JAK) inhibitors (JAKi) in the treatment A...
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#1Maryam Vaseghi-Shanjani (UBC: University of British Columbia)H-Index: 1
#2Kelsey L. Smith (UBC: University of British Columbia)
Last. Catherine M. Biggs (UBC: University of British Columbia)H-Index: 13
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Inborn errors of immunity are traditionally best known for enhancing susceptibility to infections. However, allergic inflammation, among other types of immune dysregulation, occurs frequently in patients with inborn errors of immunity. As such, the term primary atopic disorders (PADs) was recently coined to describe the group of heritable monogenic allergic disorders. It is becoming increasingly important for clinicians to recognize that allergic diseases such as food allergy, atopic dermatitis,...
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#1Rinna Tei (Mayo Clinic)
#2Koji Iijima (Mayo Clinic)H-Index: 25
Last. Hirohito Kita (Mayo Clinic)H-Index: 80
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ABSTRACT null null Background null Group 2 innate lymphoid cells (ILC2s) are involved in type 2 immune responses in mucosal organs and are associated with various allergic diseases in humans. Studies are needed to understand the molecules and pathways that control ILC2s. null null null Objective null The aim of this study was to develop a mouse model that limits the innate type 2 immune response in the lung and to investigate the immunologic mechanisms involved in regulation of lung ILC2s. null ...
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#1Allyson MatejaH-Index: 1
#2Qinlu Wang (NIH: National Institutes of Health)H-Index: 1
Last. Erica Brittain (NIH: National Institutes of Health)H-Index: 23
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Abstract null Background null Acute increases of ≥20%+2 ng/mL (20+2 rule) over basal serum tryptase (BST) is the recommended threshold supporting a clinical diagnosis of anaphylaxis. Prospective studies have demonstrated high sensitivity for this algorithm following parenteral exposures, but specificity has not been evaluated. null Objective null To define a serum tryptase change that distinguishes baseline variability from anaphylaxis based upon intraindividual variation in BST. null Methods nu...
1 CitationsSource
#1Huey-Jy Huang (Medical University of Vienna)H-Index: 7
#2Yvonne Resch-Marat (Medical University of Vienna)H-Index: 7
Last. Ekaterina Potapova (Humboldt University of Berlin)
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Background null House dust mite (HDM) allergens are major elicitors of allergic reactions worldwide. null Objective null Identification, characterization, and evaluation of diagnostic utility of a new important HDM allergen was performed. null Methods null A cDNA coding for a new Dermatophagoides pteronyssinus (Dp) allergen, Der p 37, was isolated from a Dp expression library with allergic patients' IgE antibodies. Recombinant Der p 37 (rDer p 37) expressed in Escherichia coli was purified, then...
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#1Noemi Zbären (University of Bern)H-Index: 2
#2Daniel Brigger (University of Bern)H-Index: 12
Last. Thomas Kaufmann (University of Bern)H-Index: 32
view all 11 authors...
Background null Clinical management of allergic diseases has been hampered by the lack of safe and convenient tests to reliably identify culprit allergens and to closely follow changes in disease activity over time. Because allergy diagnosis is a complex and laborious multistep procedure, there is an urgent need for simpler but still functionally accurate ex vivo assays allowing objective diagnosis, substantiating treatment choices, and quantifying therapeutic responses. null Objective null In t...
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#1Dorit Verhoeven (UvA: University of Amsterdam)H-Index: 1
#2Dieneke Schonenberg-Meinema (UvA: University of Amsterdam)H-Index: 7
Last. Sandrine Florquin (UvA: University of Amsterdam)H-Index: 85
view all 15 authors...
Abstract null Background null Proteasome associated auto-inflammatory syndromes (PRAAS) form a family of recently described rare autosomal recessive disorders of disturbed proteasome assembly and proteolytic activity caused by mutations in genes coding for proteasome subunits. Treatment options for these proteasome disorders consist of life-long immunosuppressive drugs or JAK inhibitors, which may have partial efficacy and noticeable side effects. Since proteasomes are ubiquitously expressed, it...
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