Peter G. Gibson
University of Newcastle
AirwayInternal medicineRandomized controlled trialIntensive care medicinePhysical therapyPediatricsImmunologyAsthmaRespiratory diseaseSputumCOPDInflammationExacerbationEosinophilChronic coughPregnancyExhaled nitric oxideSevere asthmaMedicine
Publications 826
#1Anne E. Vertigan ('JHCH': John Hunter Hospital)H-Index: 23
#2Sarah L. Kapela ('JHCH': John Hunter Hospital)H-Index: 2
Last. Peter G. Gibson (University of Newcastle)H-Index: 119
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Research question Objective quantification of cough is rarely utilised outside of research settings and the role of cough frequency monitoring in clinical practice has not been established. This study examined the clinical utility of cough frequency monitoring in an outpatient clinical setting. Methods The study involved a retrospective review of cough monitor data. Participants included 174 patients referred for treatment of cough and upper airway symptoms (103 chronic cough; 50 inducible laryn...
1 CitationsSource
#1Alvar Agusti (University of Barcelona)H-Index: 117
#2Neil Barnes (QMUL: Queen Mary University of London)H-Index: 70
Last. John Oppenheimer (RU: Rutgers University)H-Index: 35
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Abstract null null Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airways diseases. Both are complex and heterogeneous. Traditionally, clinical guidelines have advocated a stepwise approach to pharmacotherapy of asthma and COPD, but there is increasing realization that both require a more personalized and precise management approach. To this end, a management strategy based on the so-called Treatable Traits has been proposed. Emerging evidence suggests that thi...
#1John Blakey (SCGH: Sir Charles Gairdner Hospital)H-Index: 1
#2Li Ping Chung (Fiona Stanley Hospital)H-Index: 7
Last. Anne E Holland (Monash University)H-Index: 61
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Oral corticosteroids (OCS) are frequently used for asthma treatment. This medication is highly effective for both acute and chronic diseases, but evidence indicates that indiscriminate OCS use is common, posing a risk of serious side effects and irreversible harm. There is now an urgent need to introduce OCS stewardship approaches, akin to successful initiatives that optimized appropriate antibiotic usage. The aim of this TSANZ (Thoracic Society of Australia and New Zealand) position paper is to...
#1Paul S. Foster (University of Newcastle)H-Index: 91
#2Jessica L Barnes (University of Newcastle)
Last. Peter G. Gibson (University of Newcastle)H-Index: 119
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#1Michael Fricker (University of Newcastle)H-Index: 22
#2Ling Qin (CSU: Central South University)H-Index: 4
Last. Nazanin Z Kermani (NIH: National Institutes of Health)
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BACKGROUND Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long-lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique transcriptomic programmes reflect varied macrophage phenotypes in vitro. We aimed to determine whether airway macrophages are transcriptomically altered in NA. METHODS We performed RNASeq analysis on ...
#1Prabuddha S. Pathinayake (University of Newcastle)H-Index: 12
#2David W. Waters (University of Newcastle)H-Index: 7
Last. Jodie L. SimpsonH-Index: 57
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Introduction null The significance of endoplasmic reticulum (ER) stress in asthma is unclear. Here, we demonstrate that ER stress and the unfolded protein response (UPR) are related to disease severity and inflammatory phenotype. null Methods null Induced sputum (n=47), bronchial lavage (n=23) and endobronchial biopsies (n=40) were collected from participants with asthma with varying disease severity, inflammatory phenotypes and from healthy controls. Markers for ER stress and UPR were assessed....
#1Peter G. Gibson ('JHCH': John Hunter Hospital)H-Index: 119
#2Vanessa M. McDonald ('JHCH': John Hunter Hospital)H-Index: 35
Last. J. Tod Olin (University of Colorado Denver)H-Index: 7
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Pulmonary comorbidities can increase disease severity and health care costs associated with asthma management. Vocal cord dysfunction/inducible laryngeal obstruction is a common comorbidity that results from intermittent laryngeal obstruction. Patients describe distinct episodes of dyspnea that do not respond to bronchodilators. Inspiratory stridor is common. The gold standard diagnostic testing strategy is continuous laryngoscopy performed during exercise or irritant challenges. Dysfunctional b...
#1Marleen Bokern (UG: University of Groningen)
#2Annelies L. Robijn (University of Newcastle)H-Index: 4
Last. Michael J. Peek (ANU: Australian National University)H-Index: 24
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Background null Asthma exacerbations during pregnancy are associated with adverse pregnancy outcomes. null null null Objective null The aim of this study was to establish factors associated with asthma exacerbations during pregnancy. null null null Methods null We obtained data from three cohorts of pregnant women with asthma recruited in eastern Australia (2004-2019; n = 1461). Severe exacerbations were defined as episodes of asthma requiring hospitalization, an emergency department visit, or p...
#1Natasha A. Winter (University of Newcastle)H-Index: 1
#2Peter G. GibsonH-Index: 119
Last. Michael FrickerH-Index: 22
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Purpose null The clinical and inflammatory associations of mast cells (MCs) and basophils in chronic obstructive pulmonary disease (COPD) are poorly understood. We previously developed and validated a qPCR-based MC/basophil gene signature in asthma to measure these cells in sputum samples. Here, we measured this gene signature in a COPD and control population to explore the relationship of sputum MCs/basophils to inflammatory and COPD clinical characteristics. null Patients and methods null MC/b...
#1Scott H. Twaddell (University of Newcastle)
#2Peter G. Gibson (University of Newcastle)H-Index: 119
Last. Katherine J. Baines (University of Newcastle)H-Index: 33
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Background null Neutrophil extracellular traps (NETs) increasingly are implicated in acute and chronic conditions involving multiple organ systems. null null null Research Question null Are NET concentrations higher in parapneumonic effusions compared with effusions of other origin and does this reflect the inflammatory nature of these effusions? null null null Study Design and Methods null Patients (N = 101) seeking hospital treatment for undifferentiated pleural effusion underwent pleural flui...