Tebentafusp for uveal melanoma.

Published on Oct 8, 2021in Nature Reviews Clinical Oncology66.675
· DOI :10.1038/S41571-021-00572-3
David Killock9
Estimated H-index: 9
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Abstract
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2010
4 Authors (Kavita Mishra, ..., Devron H. Char)
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BACKGROUND Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma. Data showing a proven overall survival benefit with a systemic treatment are lacking. Tebentafusp is a bispecific protein consisting of an affinity-enhanced T-cell receptor fused to an anti-CD3 effector that can redirect T cells to target glycoprotein 100-positive cells. METHODS In this o...
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