Proteome and functional decline as platelets age in the circulation

Platelets circulate in the blood of healthy individuals for approximately 7-10 days regulated by finely balanced processes of production and destruction. As platelets are anucleate we reasoned that their protein composition would change as they age and that this change would be linked to alterations in structure and function.To isolate platelets of different ages from healthy individuals to test the hypothesis that changes in protein content...