Abstract 3174: Spatial immune cell and transcriptome profiling of tumors from primary and metastatic sites in advanced uterine serous carcinoma patients

Uterine serous carcinoma (USC) is a rare but the most aggressive subtype of endometrial cancer (EC) that represents less than 10% of all cases but contributes to more than 40% of EC related deaths. The low 5-year overall survival (OS) rate and high lethality of USC patients are mainly caused by aggressive extra-uterine metastasis frequently to lymph nodes and omentum. Deeply understanding the underneath mechanism that leads to USC progression is...