Type IV Collagenase Inhibitor, BiPS, Alters Matrix Metalloproteinase 9 Expression in Sulfur Mustard Exposed Mouse Skin

Sulfur mustard (bis‐2‐chloroethylsulfide, SM), is a chemical warfare agent that penetrates the skin rapidly causing extensive blisters and constitutes a potentially serious threat to military and civilian populations. While its mechanisms of toxic action are yet poorly defined, animal models demonstrate disruption of the skin architecture at the dermal‐epidermal junction (DEJ). Collagen degradation in the basement membrane zone by matrix...