Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
Abstract
Cell identity is maintained by activation of cell-specific gene programs, regulated by epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4)-folded regions in cells were reported to be associated with either increased or decreased transcriptional activity. By G4-ChIP-seq/RNA-seq analysis on liposarcoma cells we confirmed that G4s in promoters are invariably associated with high transcription levels in open...
Paper Details
Title
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
Published Date
Jun 23, 2021
Journal
Volume
12
Issue
1
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