Nature Communications
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#1Qifang Bi (JHU: Johns Hopkins University)H-Index: 15
#2Justin Lessler (JHU: Johns Hopkins University)H-Index: 62
Last. Idris Guessous (UNIGE: University of Geneva)H-Index: 48
view all 12 authors...
Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportionately misses mild and asymptomatic infections. Serologic measures are more likely to capture all previously infected individuals. We apply household transmission models to data from a cross-sectional, household-based population serosurvey of 4,534 peo...
#1Li CeshengH-Index: 5
#2Ding YuH-Index: 4
Last. Lu FengH-Index: 2
view all 36 authors...
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalesce...
#1Jasmine Cubuk (WUSTL: Washington University in St. Louis)H-Index: 2
#2Jhullian J Alston (WUSTL: Washington University in St. Louis)H-Index: 3
Last. Alex S. Holehouse (WUSTL: Washington University in St. Louis)H-Index: 29
view all 14 authors...
The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that contribute to N protein function. N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs. The two folded domains interact minimally such that full-leng...
#1Ping Li (Lund University)H-Index: 1
#2Kaituo Wang (UCPH: University of Copenhagen)H-Index: 8
Last. Pontus Gourdon (Lund University)H-Index: 22
view all 5 authors...
In human cells, P5B-ATPases execute the active export of physiologically important polyamines such as spermine from lysosomes to the cytosol, a function linked to a palette of disorders. Yet, the overall shape of P5B-ATPases and the mechanisms of polyamine recognition, uptake and transport remain elusive. Here we describe a series of cryo-electron microscopy structures of a yeast homolog of human ATP13A2-5, Ypk9, determined at resolutions reaching 3.4 A, and depicting three separate transport cy...
#1Ifedayo M. O. Adetifa (WT: Wellcome Trust)H-Index: 28
#2Sophie Uyoga (WT: Wellcome Trust)H-Index: 22
Last. Rashid AmanH-Index: 14
view all 35 authors...
Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with appa...
#1Daniel B. Larremore (UCB: University of Colorado Boulder)H-Index: 23
#2Derek Toomre (Yale University)H-Index: 50
Last. Roy Parker (UCB: University of Colorado Boulder)H-Index: 123
view all 3 authors...
A central problem in the COVID-19 pandemic is that there is not enough testing to prevent infectious spread of SARS-CoV-2, causing surges and lockdowns with human and economic toll. Molecular tests that detect viral RNAs or antigens will be unable to rise to this challenge unless testing capacity increases by at least an order of magnitude while decreasing turnaround times. Here, we evaluate an alternative strategy based on the monitoring of olfactory dysfunction, a symptom identified in 76–83% ...
#1Changchang Cao (CAS: Chinese Academy of Sciences)H-Index: 5
#2Zhaokui Cai (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Manman LiH-Index: 1
view all 14 authors...
#1Nils C. Gassen (University of Bonn)H-Index: 25
#2Jan Papies (HU: Humboldt-Universität zu Berlin)H-Index: 7
Last. Friderike Weege (HU: Humboldt-Universität zu Berlin)H-Index: 1
view all 35 authors...
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail, SARS-CoV-2-infected cells show accumulation of key metabolites, activation of autophagy inhibit...
#1Damien A. Leach (Imperial College London)H-Index: 12
#2Andrea Mohr (University of Essex)H-Index: 19
Last. Greg N. Brooke (University of Essex)H-Index: 14
view all 10 authors...
SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of one or both of these is thus a potential therapeutic approach for COVID-19. TMPRSS2 is a known target of the androgen receptor, a ligand-activated transcription factor; androgen receptor activation increases TMPRSS2 levels in various tissues, most notably prostate. We show here that treatment with the antiandrogen enzalutamide-a well-tole...
#1Michele Simonetti (Science for Life Laboratory)H-Index: 1
#2Ning ZhangH-Index: 1
Last. Magda Bienko (Science for Life Laboratory)H-Index: 3
view all 13 authors...
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