Late Gastrointestinal Tolerance After Prostate Radiotherapy: Is the Anal Canal the Culprit? A Narrative Critical Review.

Published on Jun 16, 2021in Frontiers in Oncology4.848
· DOI :10.3389/FONC.2021.666962
Mame Daro Faye (JGH: Jewish General Hospital), Véronique Vendrely11
Estimated H-index: 11
#1Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
#2Laura FachalH-Index: 24
Last. Catharine M L West (MAHSC: Manchester Academic Health Science Centre)H-Index: 77
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BACKGROUND: 10-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. METHODS: We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3,871) in men with European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequenc...
27 CitationsSource
#1Rano Matta (Sunnybrook Health Sciences Centre)H-Index: 2
#1Rano Matta (U of T: University of Toronto)H-Index: 4
Last. Robert K. Nam (U of T: University of Toronto)H-Index: 54
view all 10 authors...
Abstract Context Radiotherapy used for treating localized prostate cancer is effective at prolonging cancer-specific and overall survival. Still, acute and late pelvic toxicities are a concern, with gastrointestinal (GI) and genitourinary (GU) sequelae being most common as well as other pelvic complications. Objective To present a critical review of the literature regarding the incidence and risk factors of pelvic toxicity following primary radiotherapy for prostate cancer and to provide a narra...
35 CitationsSource
#1Yi Bin PanH-Index: 1
#2Yasuko Maeda (Imperial College London)H-Index: 21
Last. Carolynne J. VaizeyH-Index: 45
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AbstractIntroduction: There is a paucity of data on incidence and mechanisms of long-term gastrointestinal consequences after chemoradiotherapy for anal cancer. Most of the adverse effects reported were based on traditional external beam radiotherapy whilst only short-term follow-ups have been available for intensity-modulated radiotherapy, and there is lack of knowledge about consequences of dose-escalation radiotherapy.Method: A systematic literature review.Results: Two thousand nine hundred a...
13 CitationsSource
#1Andrew Leiker (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Neil Desai (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
Last. Michael R. Folkert (UTSW: University of Texas Southwestern Medical Center)H-Index: 19
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: Prostate cancer is the most common cancer in men. External beam radiotherapy by a variety of methods is a standard treatment option with excellent disease control. However, acute and late rectal side effects remain a limiting concern in intensification of therapy in higher-risk patients and in efforts to reduce treatment burden in others. A number of techniques have emerged that allow for high-radiation dose delivery to the prostate with reduced risk of rectal toxicity, including image-guided ...
6 CitationsSource
#1J. Langrand-EscureH-Index: 1
#2R. de Crevoisier (French Institute of Health and Medical Research)H-Index: 20
Last. C. HennequinH-Index: 19
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Abstract Considering recent phase III trials results, moderate hypofractionated radiotherapy can be considered as a standard treatment for low and intermediate risk prostate cancer management. This assessment call for a framework allowing homogeneous and reproducible practices in the different centers using this radiotherapy schedule. The French Genito-Urinary Group (GETUG) provides here recommendations for daily practice of moderate hypofractionated radiotherapy for prostate cancer, with indica...
7 CitationsSource
#1Peter Ihnát (University of Ostrava)H-Index: 10
#2Ivana Slívová (University of Ostrava)H-Index: 2
Last. Igor Penka (University of Ostrava)H-Index: 3
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Background and Objectives The aim was to evaluate the impact of radiotherapy (RT) on anorectal function of patients with low rectal cancer undergoing low anterior resection (LAR). Methods Prospective clinical cohort study conducted to assess the functional outcome by means of high-resolution anorectal manometry and LARS score. Results In total, 65 patients were enrolled in the study (27 patients underwent LAR without RT, 38 patients underwent RT and LAR). There were no statistically significant ...
14 CitationsSource
#2K. Gnep (University of Rennes)H-Index: 8
Last. Renaud de Crevoisier (University of Rennes)H-Index: 28
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BACKGROUND: To identify predictors of acute and late rectal toxicity following prostate cancer radiotherapy (RT), while integrating the potential impact of RT technique, dose escalation, and moderate hypofractionation, thus enabling us to generate a nomogram for individual prediction. METHODS: In total, 972 patients underwent RT for localized prostate cancer, to a total dose of 70 Gy or 80 Gy, using two different fractionations (2 Gy or 2.5 Gy/day), by means of several RT techniques (3D conforma...
15 CitationsSource
#1Muriel Brengues (French Institute of Health and Medical Research)H-Index: 5
#2Ariane Lapierre (University of Montpellier)H-Index: 1
Last. David Azria (University of Montpellier)H-Index: 56
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ABSTRACTIntroduction: Radiotherapy is one of the main treatments for solid tumors. The total dose that can be delivered to the tumor is limited by the radiation amount received by the surrounding normal tissues, which are at risk of developing acute and late radiation-induced effects.Areas covered: Severe late radiation-induced toxicity occurs in 5% to 10% of patients following radiotherapy. However, the current radiotherapy and radiation protection protocols do not take into account the variati...
12 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. Riccardo Valdagni (University of Milan)H-Index: 51
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Abstract Aim To investigate late gastrointestinal toxicity in a large pooled population of prostate cancer patients treated with radical radiotherapy. Normal tissue complication probability models were developed for late stool frequency and late rectal pain. Methods and materials Population included 1336 patients, 3-year minimum follow-up, treated with 66–80 Gy. Toxicity was scored with LENT-SOMA-scale. Two toxicity endpoints were considered: grade ⩾2 rectal pain and mean grade (average score du...
12 CitationsSource
#1Georges NoëlH-Index: 33
#2Delphine AntoniH-Index: 13
Last. Bruno ChauvetH-Index: 22
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Resume A partir d’une revue de la litterature, cet article definit les limites de delineation pour les organes critiques, puis les contraintes de dose sur ces derniers lorsque la radiotherapie est delivree selon un etalement et fractionnement classiques ou en hypofractionnement, tel qu’utilise dans la radiotherapie en conditions stereotaxiques.
57 CitationsSource
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