Frontiers in Oncology
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#1Livingstone Fultang (University of Birmingham)H-Index: 5
#2Luciana Gneo (University of Birmingham)H-Index: 1
Last. Francis Mussai (University of Birmingham)H-Index: 13
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Tumor cells require a higher supply of nutrients for growth and proliferation than normal cells. It is well established that metabolic reprograming in cancers for increased nutrient supply exposes a host of targetable vulnerabilities. In this article we review the documented changes in expression patterns of amino acid metabolic enzymes and transporters in myeloid malignancies and the growing list of small molecules and therapeutic strategies used to disrupt amino acid metabolic circuits within ...
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#1Xiaoting ChenH-Index: 2
Last. Shaoqiang Lin (Guangdong Pharmaceutical University)H-Index: 2
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#1Jianhao Huang (STU: Shantou University)H-Index: 1
#2Muye Song (SCUT: South China University of Technology)H-Index: 1
Last. Zeyu Wu (Peking Union Medical College)H-Index: 1
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Background Large‐volume central lymph node metastasis (large-volume CLNM) is associated with high recurrence rate in papillary thyroid carcinoma (PTC) patients. However, sensitivity in investigating large-volume CLNM on preoperative ultrasonography (US) is not high. The aim of this study is to investigate the clinical factors associated with large-volume CLNM in clinical N0 PTC patients Methods We reviewed 976 PTC patients undergoing total thyroidectomy with central lymph node dissection during ...
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#1Quan Zhou (WHU: Wuhan University)
#2Jinping Zhou (WHU: Wuhan University)
Last. Jingyi Fan (WHU: Wuhan University)
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AT-rich interaction domain 5A (ARID5A) is a member of the ARID family with a function that has been linked to autoimmune as well as inflammatory diseases. Some ARID family members are involved in the initiation and progression of human cancers. However, the function of ARID5A in glioma remains unknown. In this study, ARID5A expression levels were analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. Subsequently, the relationship between ARID5A expression and the cl...
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#1Jing LiH-Index: 7
Last. Yun BianH-Index: 4
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Objectives: This study constructed and validated a machine learning model to predict CD8+ tumor-infiltrating lymphocyte expression levels in patients with pancreatic ductal adenocarcinoma (PDAC) using CT radiomic features. Materials and Methods: In this retrospective study, 184 PDAC patients were randomly assigned to a training dataset (n =137) and validation dataset (n =47). All patients were divided into CD8+ T-high and -low groups using X-tile plots. A total of 1409 radiomics features were ex...
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#1Xiang Ye (SDU: Shandong University)
#1Xiang Ye (SDU: Shandong University)H-Index: 2
Last. Min Gao (SDU: Shandong University)H-Index: 3
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Background: Serous ovarian cancer (SOC) is a highly lethal gynecological malignancy with poor prognosis. Given the importance of the immune-related tumor microenvironment (TME) in ovarian cancer, investigating tumor-immune interactions and identifying novel prognostic and therapeutic targets in SOC is a promising avenue of research. ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a key enzyme in converting arachidonic acid to leukotriene: a crucial immune-modulating lipid mediator. H...
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#2Paolo Gallipoli (QMUL: Queen Mary University of London)H-Index: 17
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