High-dose steroids for the treatment of severe COVID-19: comment.

Published on May 26, 2021in Internal and Emergency Medicine2.322
· DOI :10.1007/S11739-021-02766-0
Shuichi Tanaka (Okayama University), Koichiro Yamamoto2
Estimated H-index: 2
(Okayama University)
+ 2 AuthorsFumio Otsuka35
Estimated H-index: 35
(Okayama University)
#1Matteo Piccica (UniFI: University of Florence)H-Index: 4
#2Filippo Lagi (UniFI: University of Florence)H-Index: 9
Last. Alessandro Bartoloni (UniFI: University of Florence)H-Index: 53
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2 CitationsSource
#2Sterne Jac. (UoB: University of Bristol)H-Index: 2
#3Srinivas Murthy (UBC: University of British Columbia)H-Index: 41
Last. John C. Marshall (St. Michael's Hospital)H-Index: 1
view all 38 authors...
Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support. Objective To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality. Design, Setting, and Participants Prospective meta-analysis that pooled data from 7 randomized...
436 CitationsSource
#2Peter HorbyH-Index: 67
#3Wei Shen LimH-Index: 37
Last. Martin J LandrayH-Index: 52
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BACKGROUND: Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death. METHODS: In this controlled, open-label trial comparing a range of possible treatments in patients who were hospitalized with Covid-19, we randomly assigned patients to receive oral or intravenous dexamethasone (at a dose of 6 mg once daily) for up to 10 days or to receive usual care...
2,123 CitationsSource
#1Sonu BhaskarH-Index: 13
#2Akansha Sinha (UNSW: University of New South Wales)H-Index: 1
Last. Shelby Kutty (Johns Hopkins University)H-Index: 36
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Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in COVID-19. Critically ill COVID-19 patients experiencing cytokine storm are believed to have a worse prognosis and increased fatality rate. In SARS-CoV-2 infected patients, cytokine storm ap...
71 CitationsSource
#1Maryam Edalatifard (Tehran University of Medical Sciences)H-Index: 3
#2Maryam Akhtari (Tehran University of Medical Sciences)H-Index: 5
Last. Abdolrahman Rostamian (Tehran University of Medical Sciences)H-Index: 4
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Background There are no determined treatment agents for the severe coronavirus disease 2019 (COVID-19); therefore, it is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of the respiratory system. Methods We conducted a single-blind, randomised, controlled, clinical trial involving severe hospitalised patients with confirmed COVID-19 at the early pulmonary phase of the illness in Iran. The patients were randomly allocated in a 1:1 ratio by block r...
35 CitationsSource
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