Fumio Otsuka
Okayama University
Internal medicineRadiologyEndocrinologySurgeryPathologyDermatologyReceptorBone morphogenetic protein 6ChemistryPediatricsGranulosa cellAldosteroneDiseasePituitary adenomaMEDLINEAngiotensin IIBone morphogenetic proteinMedicineBiologyMicrobiologyGastroenterologyCell biology
432Publications
35H-index
6,048Citations
Publications 427
Newest
#1Hideharu HagiyaH-Index: 13
#2Kou HasegawaH-Index: 5
Last. Fumio OtsukaH-Index: 35
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#1Atsuhito Suyama (Okayama University)H-Index: 1
#2Nahoko Iwata (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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The functional role of the transcription factors NR5A1 and NR5A2 and their interaction with Clock gene and bone morphogenetic proteins (BMPs) were investigated in human granulosa KGN cells. Treatment with BMP-15 and GDF-9 suppressed forskolin (FSK)-induced steroidogenesis as shown by the mRNA expression levels of StAR and P450scc but not the mRNA expression level of P450arom. Of interest, treatment with BMP-15 and GDF-9 also suppressed FSK-induced NR5A2 mRNA expression. Treatment with BMP-15 sup...
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#1Koichiro Yamamoto (Okayama University)H-Index: 2
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, involving multiple organs. We report a case of ECD with typical features of an orbital mass and "hairy kidneys," whose recognition can lead to early diagnosis and treatment.
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#1Jo Araki (Okayama University)
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), con...
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We report a case of isolated adrenocorticotropin deficiency caused by pembrolizumab. This condition can be fatal, but its rarity causes under-recognition. Oncologists should pay attention to adrenal insufficiency due to pembrolizumab.
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#1Eriko Yasutomi (Okayama University)H-Index: 4
#2Toshihiro Inokuchi (Okayama University)H-Index: 11
Last. Hiroyuki Okada (Okayama University)H-Index: 62
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Leucine-rich alpha-2 glycoprotein (LRG) may be a novel serum biomarker for patients with inflammatory bowel disease. The association of LRG with the endoscopic activity and predictability of mucosal healing (MH) was determined and compared with those of C-reactive protein (CRP) and fecal markers (fecal immunochemical test [FIT] and fecal calprotectin [Fcal]) in 166 ulcerative colitis (UC) and 56 Crohn's disease (CD) patients. In UC, LRG was correlated with the endoscopic activity and could predi...
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#1Shuichi Tanaka (Okayama University)
#2Koichiro Yamamoto (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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#1Koichiro Yamamoto (Okayama University)H-Index: 2
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
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#1Yuki Otsuka (Okayama University)H-Index: 1
#2Hideharu Hagiya (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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The gold standard for the diagnosis of coronavirus disease 2019 (COVID-19) is a nucleic acid detection test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may occasionally reveal false-positive or false-negative results. Herein, we describe a case of a patient infected with human coronavirus NL63 (HCoV-NL63) who was falsely diagnosed with COVID-19 using the Ampdirect™ 2019-nCoV detection kit (Shimadzu Corporation, Japan) and SARS-CoV-2 Detection Kit (TOYOBO co., ltd.), a...
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