101P E-cadherin inactivation by Trop-2 drives EMT-less metastatic relapse in triple-negative breast cancer

Tumor metastasis is the main cause of death for patients with triple-negative breast cancer (TNBC), and identification of metastasis drivers in TNBC is an urgent therapeutic need. Expression of target molecules in primary tumors and metastases was quantified using immunohistochemistry analysis. Cancer cell spheroids, wound healing, and cell aggregation assays were used to explore cell–cell adhesion. Pre-clinical models of metastatic diffusion...