Marco Trerotola
University of Chieti-Pescara
CancerDownregulation and upregulationPathologyCadherinMolecular biologyTranscriptomeIntegrinTransmembrane proteinMetastasisTumor progressionProstate cancerCell cycleHuman cancerProteomicsCancer researchColorectal cancerCell growthSignal transductionMedicineEpithelial–mesenchymal transitionCell adhesionFibronectinBiologyCell biologyCancer cell
49Publications
21H-index
1,102Citations
Publications 50
Newest
#1Emanuela Guerra (University of Chieti-Pescara)H-Index: 15
#2Marco Trerotola (University of Chieti-Pescara)H-Index: 21
Last. Antonino Moschella (UNIME: University of Messina)
view all 28 authors...
We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2-driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of cancer metastasis, we identified TROP2 as unique in its up-regulation across independent colon cancer metastasis models. Overexpression of wild-type Trop-2 in KM12SM human colon cancer cells increased ...
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#1Saverio AlbertiH-Index: 38
#2Emanuela GuerraH-Index: 15
view all 11 authors...
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#1Saverio AlbertiH-Index: 38
Last. Marco TrerotolaH-Index: 21
view all 11 authors...
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#1Marco Trerotola (University of Chieti-Pescara)H-Index: 21
#2Emanuela Guerra (University of Chieti-Pescara)H-Index: 15
Last. Saverio Alberti (UNIME: University of Messina)H-Index: 38
view all 15 authors...
Abstract Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, between residues R87 and T88. Molecular modeling indicated that this cleavage induces a profound rearrangement of the Trop-2 structure, which suggested a deep impact on its biological function. No Trop-2 cleavage was detected in normal human tis...
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#1Saverio AlbertiH-Index: 38
#2Marco TrerotolaH-Index: 21
Last. Emanuela GuerraH-Index: 15
view all 12 authors...
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#1Saverio Alberti (University of Chieti-Pescara)H-Index: 38
#2Emanuela Guerra (University of Chieti-Pescara)H-Index: 15
Last. Marco Trerotola (University of Chieti-Pescara)H-Index: 21
view all 5 authors...
105Background: Tumor metastasis is the main cause of death of colon cancer patients and the biggest hurdle for cancer cure. We set to identify decisive drivers and of pivotal therapy targets for co...
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#1Saverio Alberti (UNIME: University of Messina)H-Index: 38
Last. Marco TrerotolaH-Index: 21
view all 9 authors...
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#1Saverio AlbertiH-Index: 38
Last. Marco TrerotolaH-Index: 21
view all 13 authors...
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#1Daniele Vergara (University of Salento)H-Index: 26
#2Tiziano Verri (University of Salento)H-Index: 25
Last. Michele Maffia (University of Salento)H-Index: 27
view all 9 authors...
BACKGROUND: Molecular changes associated with the initiation of the epithelial to mesenchymal transition (EMT) program involve alterations of large proteome-based networks. The role of protein products mapping to non-coding genomic regions is still unexplored. OBJECTIVE: The goal of this study was the identification of an alternative protein signature in breast cancer cellular models with a distinct expression of EMT markers. METHODS: We profiled MCF-7 and MDA-MB-231 cells using liquid-chromatog...
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