Annals of Oncology
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#1Shunichi SugawaraH-Index: 25
#2Jun Suh Lee (Seoul National University Bundang Hospital)H-Index: 4
Last. C.-T. Yang (Memorial Hospital of South Bend)H-Index: 4
view all 19 authors...
BACKGROUND This international, randomized, double-blind phase III study (ONO-4538-52/TASUKI-52) evaluated nivolumab with bevacizumab and cytotoxic chemotherapy as first-line treatment for non-squamous non-small cell lung cancer (NSCLC). PATIENTS AND METHODS Between June 2017 and July 2019, this study enrolled treatment-naive patients with stage IIIB/IV or recurrent non-squamous NSCLC without sensitizing EGFR, ALK, or ROS1 alterations. They were randomly assigned in a 1:1 ratio to receive nivolum...
2 CitationsSource
#1Eric A. Klein (Cleveland Clinic)H-Index: 116
#1E.A. Klein (Cleveland Clinic)H-Index: 6
view all 15 authors...
Background null A multi-cancer early detection (MCED) test used to complement existing screening could increase the number of cancers detected through population screening, potentially improving clinical outcomes. The Circulating Cell-free Genome Atlas study (CCGA; NCT02889978) was a prospective, case-controlled, observational study and demonstrated that a blood-based MCED test utilizing cell-free DNA (cfDNA) sequencing in combination with machine learning could detect cancer signals across mult...
1 CitationsSource
#1Peter Schmid (QMUL: Queen Mary University of London)H-Index: 73
#2J. CortésH-Index: 13
Last. Rina Hui (USYD: University of Sydney)H-Index: 37
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#1Giorgio Alberto Croci (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 8
#2Rex Au-Yeung (HKU: University of Hong Kong)H-Index: 15
Last. Markus Loeffler (Leipzig University)H-Index: 84
view all 17 authors...
Abstract null null Background null Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with respect to outcome. Features of the tumor microenvironment are associated with prognosis when assessed by gene expression profiling. However, it is uncertain whether assessment of the microenvironment can add prognostic information to the most relevant and clinically well-established molecular subgroups when analyzed by immunohistochemistry. null null null Patients and Methods null We perform...
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#1Laura BargetziH-Index: 3
#2Mario Bargetzi (University of Basel)H-Index: 23
Last. Philipp Schuetz (University of Basel)H-Index: 74
view all 5 authors...
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#1M. van Gelder (UM: Maastricht University)H-Index: 8
#2Olivier TournilhacH-Index: 35
Last. Hein P.J. VisserH-Index: 2
view all 4 authors...
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#1Simone Schrodi (LMU: Ludwig Maximilian University of Munich)H-Index: 6
#2Martina BraunH-Index: 2
Last. Ingo BauerfeindH-Index: 25
view all 17 authors...
Background null Guideline recommendations for treatment of breast cancer with low hormone receptor (HR) expression (1-9%) are ambiguous and several studies showed more similarities with HR negative tumors than with HR strongly positive tumors (≥10%). We used a population-based 15-year cohort to compare patient characteristics and outcome of HR low positive tumors with HR negative and HR strongly positive tumors, respectively. null null null Patients and Methods null A total of 38,560 women diagn...
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#1N P M Brouwer (Radboud University Nijmegen)
#2Iris D. Nagtegaal (Radboud University Nijmegen)H-Index: 85
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#1Yohann Loriot (Université Paris-Saclay)H-Index: 55
#2Aurélien Marabelle (Université Paris-Saclay)H-Index: 62
Last. Caroline Even (Université Paris-Saclay)H-Index: 20
view all 19 authors...
ABSTRACT null null Background null Immune checkpoint blockers (ICBs) are now widely used in oncology. However, most patients do not derive benefit from these agents. Therefore, there is a crucial need to identify novel and reliable biomarkers of resistance to such treatments in order to prescribe potentially toxic and costly treatments only to patients with expected therapeutic benefits. In the wake of genomics, the study of proteins is now emerging as the new frontier for understanding real-tim...
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