Long-term Survival with a Rare Advanced Primary Gastrointestinal Malignant Melanoma Treated with Laparoscopic Surgery/Immune Checkpoint Inhibitor.

Published on Apr 1, 2021in Acta Medica Okayama0.642
· DOI :10.18926/AMO/61906
Motochika Endo (Okayama University), Shuya Yano25
Estimated H-index: 25
(Okayama University)
+ 11 AuthorsToshiyoshi Fujiwara63
Estimated H-index: 63
(Okayama University)
Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
#1John R. GoldblumH-Index: 108
#2Laura W. LampsH-Index: 27
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Rosai and Ackerman's surgical pathology / , Rosai and Ackerman's surgical pathology / , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
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