Toshiyoshi Fujiwara
Okayama University
CancerTelomerase reverse transcriptaseInternal medicineSurgeryPathologyOncologyApoptosisImmunologyChemotherapyOncolytic adenovirusMetastasisCancer researchColorectal cancerMedicineCell cultureOncolytic virusBiologyGastroenterologyTelomeraseCancer cell
778Publications
63H-index
11.2kCitations
Publications 775
Newest
#1Yasuhiro Shirakawa (Okayama University)H-Index: 26
#2Hiroshi Tazawa (Okayama University)H-Index: 28
Last. Satoru Kikuchi (Okayama University)H-Index: 10
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Abstract null null Purpose null OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 sensitises human cancer cells to ionising radiation by inhibiting DNA repair, and radiation enhances coxsackievirus and adenovirus receptor–mediated OBP-301 infection on the contrary. We assessed OBP-301 with radiotherapy in oesophageal cancer patients unfit for standard chemoradiation treatments. null nu...
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#1Berend R Beumer (EUR: Erasmus University Rotterdam)H-Index: 3
#2Kosei Takagi (Okayama University)H-Index: 9
Last. Jan N.M. IJzermans (EUR: Erasmus University Rotterdam)H-Index: 74
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#1Kosei Takagi (Okayama University)H-Index: 9
#2Yuzo Umeda (Okayama University)H-Index: 19
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
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BACKGROUND Contrary to the increasing incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), GEP-NETs of the accessory papilla of the duodenum are extremely rare. Furthermore, there have been no recommendations regarding the treatment strategy for GEP-NETs of the accessory papilla of the duodenum. We present a case of GEP-NET of the accessory papilla of the duodenum successfully treated with robotic pancreatoduodenectomy. CASE PRESENTATION A case of a 70-year-old complaining of no...
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#1Tetsuya Kagawa (Okayama University)H-Index: 3
#2Yuki Matsumi (Okayama University)H-Index: 3
Last. Robert M. HoffmanH-Index: 117
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Hyperthermia has been used for cancer therapy for along period of time, but has shown limited clinical efficacy. Induction-heating hyperthermia using the combination of magnetic nanoparticles (MNPs) and an alternating magnetic field (AMF), termed magnetic hyperthermia (MHT), has previously shown efficacy in an orthotopic mouse model of disseminated gastric cancer. In the present study, superparamagnetic iron oxide nanoparticles (SPIONs), atype of MNP, were conjugated with an anti-HER2 antibody, ...
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#1Yuya Sakurai (Okayama University)
#2Satoru Kikuchi (Okayama University)H-Index: 10
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
view all 21 authors...
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BACKGROUND In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive of long-term survival. This study aimed to identify an immune-nutritional index (INI) that can be used for preoperative prediction of complications. PATIENTS AND METHODS Multi-institutional data from 316 patients with ICC who had undergone surgical resection were retrospectively analysed, with a focus on various preoperative INIs. RESULTS Severe complications (Clavien-Dind...
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#1Yuki Matsumi (Okayama University)H-Index: 3
#2Tetsuya Kagawa (Okayama University)H-Index: 3
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
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Magnetic hyperthermia (MHT), which combines magnetic nanoparticles (MNPs) with an alternating magnetic field (AMF), holds promise as a cancer therapy. There have been many studies about hyperthermia, most of which have been performed by direct injection of MNPs into tumor tissues. However, there have been no reports of treating peritoneal disseminated disease with MHT to date. In the present study, we treated peritoneal metastasis of gastric cancer with MHT using superparamagnetic iron oxide (Fe...
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#1Kazuhisa Sugiu (Okayama University)H-Index: 4
#2Hiroshi Tazawa (Okayama University)H-Index: 28
Last. Tomohiro Fujiwara (Okayama University)H-Index: 16
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BACKGROUND Osteosarcoma (OS) is a malignant bone tumor primarily affecting children and adolescents. The prognosis of chemotherapy-refractory OS patients is poor. We developed a tumor suppressor p53-expressing oncolytic adenovirus (OBP-702) that exhibits antitumor effects against human OS cells. Here, we demonstrate the chemosensitizing effect of OBP-702 in human OS cells. MATERIALS AND METHODS The in vitro and in vivo antitumor activities of doxorubicin (DOX) and OBP-702 were assessed using par...
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#1Tomohiro Fujiwara (Okayama University)H-Index: 16
#2Mohamed A Yakoub (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. John H. Healey (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 97
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Colony-stimulating factor 1 (CSF-1) is a primary regulator of the survival, proliferation, and differentiation of monocyte/macrophage that sustains the pro-tumorigenic functions of tumor-associated macrophages (TAMs). Considering current advances in understanding the role of the inflammatory tumor microenvironment, targeting the components of the sarcoma microenvironment, such as TAMs, is a viable strategy. Here, we investigated the effect of PLX3397 (pexidartinib) as a potent inhibitor of the C...
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#1Satoru Kikuchi (Okayama University)H-Index: 10
#2Tetsuya KagawaH-Index: 3
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
view all 13 authors...
PURPOSE The Endoscopic Surgical Skill Quantification System for qualified surgeons (QSs) was introduced in Japan to improve surgical outcomes. This study reviewed the surgical outcomes after initial experience performing laparoscopic distal gastrectomy (LDG) and evaluated the improvement in surgical outcomes following accreditation as a QS. METHODS Eighty-seven consecutive patients who underwent LDG for gastric cancer by a single surgeon were enrolled in this study. The cumulative sum method was...
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