Association of plasma EFEMP1 with brain aging and dementia

Background Biological pathways underlying the association between white matter hyperintensities (WMH) and Alzheimer’s disease (AD) dementia remain poorly understood. Epidermal growth factor containing fibulin extracellular matrix protein‐1 (EFEMP1) has been associated with increased WMH burden and disorders of premature aging. However, it is unknown if elevated circulating EFEMP1 is associated with clinical dementia. We determined the...