Original paper
The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis
Abstract
Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell lines, and orthotopic mouse models. We demonstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis...
Paper Details
Title
The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis
Published Date
Nov 4, 2020
Journal
Volume
40
Issue
2
Pages
384 - 395
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Notes
History